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Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1.

Publication ,  Journal Article
Murphy, D; Bishop, A; Rindi, G; Murphy, MN; Stamp, GW; Hanson, J; Polak, JM; Hogan, B
Published in: Am J Pathol
December 1987

The authors have used transgenic mice to study the activity of a hybrid oncogene made up of 1.25 kb of 5' upstream sequences, derived from the bovine vasopressin gene, promoting the expression of the large T-antigen coding sequences of the early region of simian virus 40. Rather than promoting tumorigenesis in vasopressinergic cells of the hypothalamus, expression and activity of the hybrid oncogene, and consequent tumor formation, were confined to insulin-producing beta cells of the endocrine pancreas and to cells in the anterior pituitary. These observations suggest that the specificity of vasopressin gene expression normally results from an interaction between several regulatory elements, some of which are absent from the hybrid oncogene. The possible relationship between the endocrine tumor syndrome found in the vasopressin-SV40 transgenic mice and familial human multiple endocrine neoplasia is discussed.

Duke Scholars

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

December 1987

Volume

129

Issue

3

Start / End Page

552 / 566

Location

United States

Related Subject Headings

  • Simian virus 40
  • Pituitary Neoplasms
  • Pituitary Gland, Anterior
  • Pathology
  • Pancreatic Neoplasms
  • Oncogenes
  • Microscopy, Electron
  • Mice, Transgenic
  • Mice
  • Immunohistochemistry
 

Citation

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Murphy, D., Bishop, A., Rindi, G., Murphy, M. N., Stamp, G. W., Hanson, J., … Hogan, B. (1987). Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1. Am J Pathol, 129(3), 552–566.
Murphy, D., A. Bishop, G. Rindi, M. N. Murphy, G. W. Stamp, J. Hanson, J. M. Polak, and B. Hogan. “Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1.Am J Pathol 129, no. 3 (December 1987): 552–66.
Journal cover image

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

December 1987

Volume

129

Issue

3

Start / End Page

552 / 566

Location

United States

Related Subject Headings

  • Simian virus 40
  • Pituitary Neoplasms
  • Pituitary Gland, Anterior
  • Pathology
  • Pancreatic Neoplasms
  • Oncogenes
  • Microscopy, Electron
  • Mice, Transgenic
  • Mice
  • Immunohistochemistry