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A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.

Publication ,  Journal Article
Jackson, IJ; Schofield, P; Hogan, B
Published in: Nature
October 24, 1985

The homoeo box sequence of Drosophila is an element located in several genes that regulate segmentation and segment identity; it has homologues in the genomes of vertebrate species and a number of homoeo box-containing recombinant DNA clones have been isolated from Xenopus, man and mouse. In the present study we have isolated from a library of murine DNA a recombinant lambda clone (H24.1) which contains a sequence closely homologous to the homoeo box within the Drosophila Antennapedia (Antp) gene. The protein sequence of the homoeo domain is identical to that encoded by Hu-1, one of a the pair of closely linked homoeo boxes in the human genome. We have used a sensitive RNase protection assay to examine transcription of the H24.1 gene during mouse development, and in adult tissues. We report that the gene is transcribed from as early as 7.5 days post coitum (p.c.), with maximum expression at days 11.5 and 12.5 p.c. The transcript is enriched in embryonic spinal cord and brain at day 12.5 p.c., and in adult kidney.

Duke Scholars

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 24, 1985

Volume

317

Issue

6039

Start / End Page

745 / 748

Location

England

Related Subject Headings

  • Spinal Cord
  • Sequence Homology, Nucleic Acid
  • Mice
  • Kidney
  • Genes, Regulator
  • General Science & Technology
  • Gene Expression Regulation
  • Cloning, Molecular
  • Brain
  • Base Sequence
 

Citation

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Jackson, I. J., Schofield, P., & Hogan, B. (1985). A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. Nature, 317(6039), 745–748. https://doi.org/10.1038/317745a0
Jackson, I. J., P. Schofield, and B. Hogan. “A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.Nature 317, no. 6039 (October 24, 1985): 745–48. https://doi.org/10.1038/317745a0.
Jackson IJ, Schofield P, Hogan B. A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. Nature. 1985 Oct 24;317(6039):745–8.
Jackson, I. J., et al. “A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.Nature, vol. 317, no. 6039, Oct. 1985, pp. 745–48. Pubmed, doi:10.1038/317745a0.
Jackson IJ, Schofield P, Hogan B. A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. Nature. 1985 Oct 24;317(6039):745–748.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 24, 1985

Volume

317

Issue

6039

Start / End Page

745 / 748

Location

England

Related Subject Headings

  • Spinal Cord
  • Sequence Homology, Nucleic Acid
  • Mice
  • Kidney
  • Genes, Regulator
  • General Science & Technology
  • Gene Expression Regulation
  • Cloning, Molecular
  • Brain
  • Base Sequence