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Primary chemotherapy in epithelial ovarian cancer.

Publication ,  Journal Article
Hurwitz, HI; McGuire, WP
Published in: Obstet Gynecol Clin North Am
March 1994

Ovarian cancer is an important disease due to its occurrence in women in the prime of life (40-70) and its responsiveness to therapy but generally poor outcome due to the emergence of drug-resistant cells. In early-stage disease, adjuvant therapies may improve outcome, but previous studies have concentrated more on the reduction of toxicity of therapy than on improved survival, although modern approaches are evaluating more aggressive intervention in these patients with good survival rates (40%-90% cure with surgery). In advanced disease, the most common presentation, it appears that more aggressive staging and surgical debulking as well as new classes of drugs for treatment have altered, albeit modestly, the outcome in this disease. Future approaches will evaluate taxol, a new active agent, as well as more dose-intense therapy and a continued search will be made for new active drugs and methods to overcome intrinsic and acquired drug resistance.

Duke Scholars

Published In

Obstet Gynecol Clin North Am

ISSN

0889-8545

Publication Date

March 1994

Volume

21

Issue

1

Start / End Page

141 / 154

Location

United States

Related Subject Headings

  • Paclitaxel
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
  • Middle Aged
  • Humans
  • Female
  • Cisplatin
  • Antineoplastic Combined Chemotherapy Protocols
 

Citation

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Chicago
ICMJE
MLA
NLM
Hurwitz, H. I., & McGuire, W. P. (1994). Primary chemotherapy in epithelial ovarian cancer. Obstet Gynecol Clin North Am, 21(1), 141–154.
Hurwitz, H. I., and W. P. McGuire. “Primary chemotherapy in epithelial ovarian cancer.Obstet Gynecol Clin North Am 21, no. 1 (March 1994): 141–54.
Hurwitz HI, McGuire WP. Primary chemotherapy in epithelial ovarian cancer. Obstet Gynecol Clin North Am. 1994 Mar;21(1):141–54.
Hurwitz, H. I., and W. P. McGuire. “Primary chemotherapy in epithelial ovarian cancer.Obstet Gynecol Clin North Am, vol. 21, no. 1, Mar. 1994, pp. 141–54.
Hurwitz HI, McGuire WP. Primary chemotherapy in epithelial ovarian cancer. Obstet Gynecol Clin North Am. 1994 Mar;21(1):141–154.
Journal cover image

Published In

Obstet Gynecol Clin North Am

ISSN

0889-8545

Publication Date

March 1994

Volume

21

Issue

1

Start / End Page

141 / 154

Location

United States

Related Subject Headings

  • Paclitaxel
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
  • Middle Aged
  • Humans
  • Female
  • Cisplatin
  • Antineoplastic Combined Chemotherapy Protocols