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Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.

Publication ,  Journal Article
Chen, CY; Hall, I; Lansing, TJ; Gilmer, TM; Tlsty, TD; Kastan, MB
Published in: Cancer Res
August 15, 1996

The tumor suppressor gene product, p53, appears to be a significant participant in signaling pathways that mediate cellular responses to cytotoxic stresses. In particular, p53 appears to be a critical determinant of whether the cell lives or dies and how it progresses through the cell cycle after the cytotoxic exposure. Many of the molecular details for these signaling pathways remain to be elucidated, and whether all cytotoxic signals utilize the same pathway to increase p53 expression is not clear. Here, we demonstrate the existence of cell types in which the induction of p53 and associated G1 arrest by the antimetabolite, N-(phosphonoacetyl)-L-aspartate (PALA), is defective, whereas p53 induction and G1 arrest induced by ionizing radiation are intact. These observations demonstrate the existence of genetic defects that can alter p53 induction and associated cellular outcomes after some, but not all, cytotoxic insults and suggest distinct pathways of p53 induction by PALA and ionizing radiation.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

August 15, 1996

Volume

56

Issue

16

Start / End Page

3659 / 3662

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Phosphonoacetic Acid
  • Oncology & Carcinogenesis
  • Molecular Sequence Data
  • Humans
  • Genes, p53
  • Gene Expression Regulation
  • DNA Damage
  • Cell Line
  • Cell Cycle
 

Citation

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Chen, C. Y., Hall, I., Lansing, T. J., Gilmer, T. M., Tlsty, T. D., & Kastan, M. B. (1996). Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. Cancer Res, 56(16), 3659–3662.
Chen, C. Y., I. Hall, T. J. Lansing, T. M. Gilmer, T. D. Tlsty, and M. B. Kastan. “Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.Cancer Res 56, no. 16 (August 15, 1996): 3659–62.
Chen CY, Hall I, Lansing TJ, Gilmer TM, Tlsty TD, Kastan MB. Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. Cancer Res. 1996 Aug 15;56(16):3659–62.
Chen, C. Y., et al. “Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.Cancer Res, vol. 56, no. 16, Aug. 1996, pp. 3659–62.
Chen CY, Hall I, Lansing TJ, Gilmer TM, Tlsty TD, Kastan MB. Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. Cancer Res. 1996 Aug 15;56(16):3659–3662.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

August 15, 1996

Volume

56

Issue

16

Start / End Page

3659 / 3662

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Phosphonoacetic Acid
  • Oncology & Carcinogenesis
  • Molecular Sequence Data
  • Humans
  • Genes, p53
  • Gene Expression Regulation
  • DNA Damage
  • Cell Line
  • Cell Cycle