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Signalling to p53: where does it all start?

Publication ,  Journal Article
Kastan, MB
Published in: Bioessays
August 1996

Alterations in the p53 gene product appear to be a major factor in human tumorigenesis and may influence the responses of many human tumors to therapy. Much effort has focused on understanding the signals which normally initiate p53 growth-suppressive functions. Though it has been known that DNA damage can induce p53, a recent publication reports data which suggest that p53 can be induced by depletion of ribonucleotide pools, even in the absence of detectable DNA damage(1). These observations provide new ideas about how cells utilize the p53 signal and open up new avenues of investigation for manipulating p53 function.

Duke Scholars

Published In

Bioessays

DOI

ISSN

0265-9247

Publication Date

August 1996

Volume

18

Issue

8

Start / End Page

617 / 619

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Humans
  • Genes, p53
  • Developmental Biology
  • Cell Transformation, Neoplastic
  • Animals
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Kastan, M. B. (1996). Signalling to p53: where does it all start? Bioessays, 18(8), 617–619. https://doi.org/10.1002/bies.950180804
Kastan, M. B. “Signalling to p53: where does it all start?Bioessays 18, no. 8 (August 1996): 617–19. https://doi.org/10.1002/bies.950180804.
Kastan MB. Signalling to p53: where does it all start? Bioessays. 1996 Aug;18(8):617–9.
Kastan, M. B. “Signalling to p53: where does it all start?Bioessays, vol. 18, no. 8, Aug. 1996, pp. 617–19. Pubmed, doi:10.1002/bies.950180804.
Kastan MB. Signalling to p53: where does it all start? Bioessays. 1996 Aug;18(8):617–619.
Journal cover image

Published In

Bioessays

DOI

ISSN

0265-9247

Publication Date

August 1996

Volume

18

Issue

8

Start / End Page

617 / 619

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Humans
  • Genes, p53
  • Developmental Biology
  • Cell Transformation, Neoplastic
  • Animals
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences