Skip to main content
Journal cover image

Induction of apoptosis by tumor suppressor genes and oncogenes.

Publication ,  Journal Article
Canman, CE; Kastan, MB
Published in: Semin Cancer Biol
February 1995

The p53 tumor suppressor gene product, and the bcr-abl, bcl-2, and c-myc gene products all appear to influence the susceptibility of cells to apoptosis. In addition to the role p53 protein plays in mediating a cell cycle arrest in G1 following DNA damage, p53 also performs functions critical for removal of damaged cells by initiating apoptosis in certain physiological situations. Cells which express deregulated c-myc are sensitized to apoptosis following various growth suppressing stimuli and these observations have provided new insights into how apoptosis-suppressing genes such as mutant p53, bcl-2 and bcr-abl may cooperate during transformation and how they might influence the sensitivity of cells to radiation and chemotherapy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Semin Cancer Biol

DOI

ISSN

1044-579X

Publication Date

February 1995

Volume

6

Issue

1

Start / End Page

17 / 25

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Oncogenes
  • Humans
  • Genes, Tumor Suppressor
  • Apoptosis
  • Animals
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Canman, C. E., & Kastan, M. B. (1995). Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol, 6(1), 17–25. https://doi.org/10.1006/scbi.1995.0003
Canman, C. E., and M. B. Kastan. “Induction of apoptosis by tumor suppressor genes and oncogenes.Semin Cancer Biol 6, no. 1 (February 1995): 17–25. https://doi.org/10.1006/scbi.1995.0003.
Canman CE, Kastan MB. Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol. 1995 Feb;6(1):17–25.
Canman, C. E., and M. B. Kastan. “Induction of apoptosis by tumor suppressor genes and oncogenes.Semin Cancer Biol, vol. 6, no. 1, Feb. 1995, pp. 17–25. Pubmed, doi:10.1006/scbi.1995.0003.
Canman CE, Kastan MB. Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol. 1995 Feb;6(1):17–25.
Journal cover image

Published In

Semin Cancer Biol

DOI

ISSN

1044-579X

Publication Date

February 1995

Volume

6

Issue

1

Start / End Page

17 / 25

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Oncogenes
  • Humans
  • Genes, Tumor Suppressor
  • Apoptosis
  • Animals
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis