Induction of apoptosis by tumor suppressor genes and oncogenes.
Publication
, Journal Article
Canman, CE; Kastan, MB
Published in: Semin Cancer Biol
February 1995
The p53 tumor suppressor gene product, and the bcr-abl, bcl-2, and c-myc gene products all appear to influence the susceptibility of cells to apoptosis. In addition to the role p53 protein plays in mediating a cell cycle arrest in G1 following DNA damage, p53 also performs functions critical for removal of damaged cells by initiating apoptosis in certain physiological situations. Cells which express deregulated c-myc are sensitized to apoptosis following various growth suppressing stimuli and these observations have provided new insights into how apoptosis-suppressing genes such as mutant p53, bcl-2 and bcr-abl may cooperate during transformation and how they might influence the sensitivity of cells to radiation and chemotherapy.
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Published In
Semin Cancer Biol
DOI
ISSN
1044-579X
Publication Date
February 1995
Volume
6
Issue
1
Start / End Page
17 / 25
Location
England
Related Subject Headings
- Oncology & Carcinogenesis
- Oncogenes
- Humans
- Genes, Tumor Suppressor
- Apoptosis
- Animals
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Canman, C. E., & Kastan, M. B. (1995). Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol, 6(1), 17–25. https://doi.org/10.1006/scbi.1995.0003
Canman, C. E., and M. B. Kastan. “Induction of apoptosis by tumor suppressor genes and oncogenes.” Semin Cancer Biol 6, no. 1 (February 1995): 17–25. https://doi.org/10.1006/scbi.1995.0003.
Canman CE, Kastan MB. Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol. 1995 Feb;6(1):17–25.
Canman, C. E., and M. B. Kastan. “Induction of apoptosis by tumor suppressor genes and oncogenes.” Semin Cancer Biol, vol. 6, no. 1, Feb. 1995, pp. 17–25. Pubmed, doi:10.1006/scbi.1995.0003.
Canman CE, Kastan MB. Induction of apoptosis by tumor suppressor genes and oncogenes. Semin Cancer Biol. 1995 Feb;6(1):17–25.
Published In
Semin Cancer Biol
DOI
ISSN
1044-579X
Publication Date
February 1995
Volume
6
Issue
1
Start / End Page
17 / 25
Location
England
Related Subject Headings
- Oncology & Carcinogenesis
- Oncogenes
- Humans
- Genes, Tumor Suppressor
- Apoptosis
- Animals
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
- 1112 Oncology and Carcinogenesis