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P53, cell cycle control and apoptosis: implications for cancer.

Publication ,  Journal Article
Kastan, MB; Canman, CE; Leonard, CJ
Published in: Cancer Metastasis Rev
March 1995

Cellular proliferation depends on the rates of both cell division and cell death. Tumors frequently have decreased cell death as a primary mode of increased cell proliferation. Genetic changes resulting in loss of programmed cell death (apoptosis) are likely to be critical components of tumorigenesis. Many of the gene products which appear to control apoptotic tendencies are regulators of cell cycle progression; thus, cell cycle control and cell death appear to be tightly linked processes. P53 protein is an example of a gene product which affects both cell cycle progression and apoptosis. The ability of p53 overexpression to induce apoptosis may be a major reason why tumor cells frequently disable p53 during the transformation process. Unfortunately, the same genetic changes which cause loss of apoptosis during tumor development, may also result in tumor cell resistance to anti-neoplastic therapies which kill tumor cells by apoptosis. Elucidation of the genetic and biochemical controls of these cellular responses may provide insights into ways to induce cell death and thus hopefully suggest new targets for improving therapeutic index in the treatment of malignancies.

Duke Scholars

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Published In

Cancer Metastasis Rev

DOI

ISSN

0167-7659

Publication Date

March 1995

Volume

14

Issue

1

Start / End Page

3 / 15

Location

Netherlands

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Humans
  • Genes, p53
  • Gene Expression Regulation
  • G1 Phase
  • DNA Damage
  • Cell Transformation, Neoplastic
 

Citation

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Kastan, M. B., Canman, C. E., & Leonard, C. J. (1995). P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev, 14(1), 3–15. https://doi.org/10.1007/BF00690207
Kastan, M. B., C. E. Canman, and C. J. Leonard. “P53, cell cycle control and apoptosis: implications for cancer.Cancer Metastasis Rev 14, no. 1 (March 1995): 3–15. https://doi.org/10.1007/BF00690207.
Kastan MB, Canman CE, Leonard CJ. P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev. 1995 Mar;14(1):3–15.
Kastan, M. B., et al. “P53, cell cycle control and apoptosis: implications for cancer.Cancer Metastasis Rev, vol. 14, no. 1, Mar. 1995, pp. 3–15. Pubmed, doi:10.1007/BF00690207.
Kastan MB, Canman CE, Leonard CJ. P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev. 1995 Mar;14(1):3–15.
Journal cover image

Published In

Cancer Metastasis Rev

DOI

ISSN

0167-7659

Publication Date

March 1995

Volume

14

Issue

1

Start / End Page

3 / 15

Location

Netherlands

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Humans
  • Genes, p53
  • Gene Expression Regulation
  • G1 Phase
  • DNA Damage
  • Cell Transformation, Neoplastic