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The role of hematopoietic growth factors and oncogenes in leukemogenesis.

Publication ,  Journal Article
Kastan, MB; Strauss, LC; Civin, CI
Published in: Am J Pediatr Hematol Oncol
1989

Understanding of the roles and molecular mechanisms of hematopoietic growth factors has increased greatly in recent years. This past decade has also brought us tantalizingly close to linking a group of genes normally involved in the regulation of growth and differentiation--the cellular proto-oncogenes--to the process of malignant transformation. In this article, we review the known actions of hematopoietic growth factors in normal hematopoiesis and in hematologic malignancies. We then discuss current concepts of the roles of proto-oncogenes in normal cells and their potential involvement in leukemogenic events. A merging of these concepts with classical hypotheses of multistage carcinogenesis is emphasized.

Duke Scholars

Published In

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Publication Date

1989

Volume

11

Issue

3

Start / End Page

249 / 267

Location

United States

Related Subject Headings

  • Proto-Oncogenes
  • Leukemia
  • Humans
  • Hematopoietic Stem Cells
  • Hematopoietic Cell Growth Factors
  • Growth Substances
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kastan, M. B., Strauss, L. C., & Civin, C. I. (1989). The role of hematopoietic growth factors and oncogenes in leukemogenesis. Am J Pediatr Hematol Oncol, 11(3), 249–267.
Kastan, M. B., L. C. Strauss, and C. I. Civin. “The role of hematopoietic growth factors and oncogenes in leukemogenesis.Am J Pediatr Hematol Oncol 11, no. 3 (1989): 249–67.
Kastan MB, Strauss LC, Civin CI. The role of hematopoietic growth factors and oncogenes in leukemogenesis. Am J Pediatr Hematol Oncol. 1989;11(3):249–67.
Kastan, M. B., et al. “The role of hematopoietic growth factors and oncogenes in leukemogenesis.Am J Pediatr Hematol Oncol, vol. 11, no. 3, 1989, pp. 249–67.
Kastan MB, Strauss LC, Civin CI. The role of hematopoietic growth factors and oncogenes in leukemogenesis. Am J Pediatr Hematol Oncol. 1989;11(3):249–267.

Published In

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Publication Date

1989

Volume

11

Issue

3

Start / End Page

249 / 267

Location

United States

Related Subject Headings

  • Proto-Oncogenes
  • Leukemia
  • Humans
  • Hematopoietic Stem Cells
  • Hematopoietic Cell Growth Factors
  • Growth Substances