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Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.

Publication ,  Journal Article
Kuhn, C; Albright, K; Francis, R
Published in: Life Sci
1991

Corticotropin releasing factor (CRF) both stimulates ACTH secretion from the pituitary and inhibits secretion of growth hormone (GH) in adult rats through actions in the CNS. The purpose of the present study was to evaluate these pituitary and central actions of CRF in neonatal rats, in which the hypothalamo- pituitary adrenal (HPA) axis is relatively hypo-functional. The results of this study show that central or peripheral administration of CRF evokes a marked dose-related rise in serum corticosterone in 6-day old rats. The same doses of CRF stimulate, rather than inhibit GH secretion. These results suggest that CRF has unique central actions early in ontogeny.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1991

Volume

49

Issue

19

Start / End Page

1427 / 1434

Location

Netherlands

Related Subject Headings

  • Rats
  • Random Allocation
  • Radioimmunoassay
  • Pharmacology & Pharmacy
  • Male
  • Hypothalamo-Hypophyseal System
  • Growth Hormone
  • Female
  • Dose-Response Relationship, Drug
  • Corticotropin-Releasing Hormone
 

Citation

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Kuhn, C., Albright, K., & Francis, R. (1991). Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. Life Sci, 49(19), 1427–1434. https://doi.org/10.1016/0024-3205(91)90395-r
Kuhn, C., K. Albright, and R. Francis. “Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.Life Sci 49, no. 19 (1991): 1427–34. https://doi.org/10.1016/0024-3205(91)90395-r.
Kuhn C, Albright K, Francis R. Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. Life Sci. 1991;49(19):1427–34.
Kuhn, C., et al. “Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.Life Sci, vol. 49, no. 19, 1991, pp. 1427–34. Pubmed, doi:10.1016/0024-3205(91)90395-r.
Kuhn C, Albright K, Francis R. Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. Life Sci. 1991;49(19):1427–1434.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1991

Volume

49

Issue

19

Start / End Page

1427 / 1434

Location

Netherlands

Related Subject Headings

  • Rats
  • Random Allocation
  • Radioimmunoassay
  • Pharmacology & Pharmacy
  • Male
  • Hypothalamo-Hypophyseal System
  • Growth Hormone
  • Female
  • Dose-Response Relationship, Drug
  • Corticotropin-Releasing Hormone