Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.
Publication
, Journal Article
Kuhn, C; Albright, K; Francis, R
Published in: Life Sci
1991
Corticotropin releasing factor (CRF) both stimulates ACTH secretion from the pituitary and inhibits secretion of growth hormone (GH) in adult rats through actions in the CNS. The purpose of the present study was to evaluate these pituitary and central actions of CRF in neonatal rats, in which the hypothalamo- pituitary adrenal (HPA) axis is relatively hypo-functional. The results of this study show that central or peripheral administration of CRF evokes a marked dose-related rise in serum corticosterone in 6-day old rats. The same doses of CRF stimulate, rather than inhibit GH secretion. These results suggest that CRF has unique central actions early in ontogeny.
Duke Scholars
Published In
Life Sci
DOI
ISSN
0024-3205
Publication Date
1991
Volume
49
Issue
19
Start / End Page
1427 / 1434
Location
Netherlands
Related Subject Headings
- Rats
- Random Allocation
- Radioimmunoassay
- Pharmacology & Pharmacy
- Male
- Hypothalamo-Hypophyseal System
- Growth Hormone
- Female
- Dose-Response Relationship, Drug
- Corticotropin-Releasing Hormone
Citation
APA
Chicago
ICMJE
MLA
NLM
Kuhn, C., Albright, K., & Francis, R. (1991). Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. Life Sci, 49(19), 1427–1434. https://doi.org/10.1016/0024-3205(91)90395-r
Kuhn, C., K. Albright, and R. Francis. “Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.” Life Sci 49, no. 19 (1991): 1427–34. https://doi.org/10.1016/0024-3205(91)90395-r.
Kuhn C, Albright K, Francis R. Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. Life Sci. 1991;49(19):1427–34.
Kuhn, C., et al. “Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.” Life Sci, vol. 49, no. 19, 1991, pp. 1427–34. Pubmed, doi:10.1016/0024-3205(91)90395-r.
Kuhn C, Albright K, Francis R. Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. Life Sci. 1991;49(19):1427–1434.
Published In
Life Sci
DOI
ISSN
0024-3205
Publication Date
1991
Volume
49
Issue
19
Start / End Page
1427 / 1434
Location
Netherlands
Related Subject Headings
- Rats
- Random Allocation
- Radioimmunoassay
- Pharmacology & Pharmacy
- Male
- Hypothalamo-Hypophyseal System
- Growth Hormone
- Female
- Dose-Response Relationship, Drug
- Corticotropin-Releasing Hormone