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Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.

Publication ,  Journal Article
Ignar, DM; Kuhn, CM
Published in: Endocrinology
July 1988

In order to study the ontogeny of TSH regulation in the rat, we have compared TSH secretion in neonatal and adult rats after treatment with morphine, TRH and apomorphine, clonidine, and exposure to cold. Apomorphine attenuated exogenous TRH-induced TSH release in both neonatal and adult rats. Morphine suppressed TSH levels at every age tested. Although clonidine and cold exposure elicited TSH secretion in adults, neonatal rats did not respond to either treatment. These findings suggest that opioid and dopaminergic controls of TSH release mature before central noradrenergic regulation in developing rats. This lack of noradrenergic control may account for the absence of the response to cold exposure in the neonate.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

July 1988

Volume

123

Issue

1

Start / End Page

567 / 571

Location

United States

Related Subject Headings

  • Thyrotropin-Releasing Hormone
  • Thyrotropin
  • Rats, Inbred Strains
  • Rats
  • Naloxone
  • Morphine
  • Male
  • Endocrinology & Metabolism
  • Corticosterone
  • Cold Temperature
 

Citation

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Ignar, D. M., & Kuhn, C. M. (1988). Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. Endocrinology, 123(1), 567–571. https://doi.org/10.1210/endo-123-1-567
Ignar, D. M., and C. M. Kuhn. “Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.Endocrinology 123, no. 1 (July 1988): 567–71. https://doi.org/10.1210/endo-123-1-567.
Ignar, D. M., and C. M. Kuhn. “Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.Endocrinology, vol. 123, no. 1, July 1988, pp. 567–71. Pubmed, doi:10.1210/endo-123-1-567.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

July 1988

Volume

123

Issue

1

Start / End Page

567 / 571

Location

United States

Related Subject Headings

  • Thyrotropin-Releasing Hormone
  • Thyrotropin
  • Rats, Inbred Strains
  • Rats
  • Naloxone
  • Morphine
  • Male
  • Endocrinology & Metabolism
  • Corticosterone
  • Cold Temperature