Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.
Publication
, Journal Article
Ignar, DM; Kuhn, CM
Published in: Endocrinology
July 1988
In order to study the ontogeny of TSH regulation in the rat, we have compared TSH secretion in neonatal and adult rats after treatment with morphine, TRH and apomorphine, clonidine, and exposure to cold. Apomorphine attenuated exogenous TRH-induced TSH release in both neonatal and adult rats. Morphine suppressed TSH levels at every age tested. Although clonidine and cold exposure elicited TSH secretion in adults, neonatal rats did not respond to either treatment. These findings suggest that opioid and dopaminergic controls of TSH release mature before central noradrenergic regulation in developing rats. This lack of noradrenergic control may account for the absence of the response to cold exposure in the neonate.
Duke Scholars
Published In
Endocrinology
DOI
ISSN
0013-7227
Publication Date
July 1988
Volume
123
Issue
1
Start / End Page
567 / 571
Location
United States
Related Subject Headings
- Thyrotropin-Releasing Hormone
- Thyrotropin
- Rats, Inbred Strains
- Rats
- Naloxone
- Morphine
- Male
- Endocrinology & Metabolism
- Corticosterone
- Cold Temperature
Citation
APA
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ICMJE
MLA
NLM
Ignar, D. M., & Kuhn, C. M. (1988). Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. Endocrinology, 123(1), 567–571. https://doi.org/10.1210/endo-123-1-567
Ignar, D. M., and C. M. Kuhn. “Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.” Endocrinology 123, no. 1 (July 1988): 567–71. https://doi.org/10.1210/endo-123-1-567.
Ignar DM, Kuhn CM. Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. Endocrinology. 1988 Jul;123(1):567–71.
Ignar, D. M., and C. M. Kuhn. “Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.” Endocrinology, vol. 123, no. 1, July 1988, pp. 567–71. Pubmed, doi:10.1210/endo-123-1-567.
Ignar DM, Kuhn CM. Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. Endocrinology. 1988 Jul;123(1):567–571.
Published In
Endocrinology
DOI
ISSN
0013-7227
Publication Date
July 1988
Volume
123
Issue
1
Start / End Page
567 / 571
Location
United States
Related Subject Headings
- Thyrotropin-Releasing Hormone
- Thyrotropin
- Rats, Inbred Strains
- Rats
- Naloxone
- Morphine
- Male
- Endocrinology & Metabolism
- Corticosterone
- Cold Temperature