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Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.

Publication ,  Journal Article
Bero, LA; Lurie, SN; Kuhn, CM
Published in: Brain Res
December 15, 1987

Although both mu- and kappa-opioid components of prolactin (PRL) secretion have been identified in the adult rat, the neural pathways through which these multiple receptor subtypes modulate PRL secretion have not been thoroughly investigated. The present study utilizes the differential ontogeny of opioid systems which alter PRL release to examine the mechanisms by which mu- and kappa-receptors regulate prolactin. The responses of PRL, corticosterone and growth hormone to opioid receptor subtype-specific agonists were studied in neonatal rats. The PRL response to the kappa-agonist, U50488, preceded the response to the mu-agonist, morphiceptin. Like adults, neonates demonstrated a growth hormone, but not a PRL, response to the delta agonist, [D-pen2,pen5]enkephalin. U50488-induced PRL secretion was not attenuated by cyproheptadine in adults or neonates, suggesting that the kappa-opioid mechanism operates independently of serotonin. In contrast, the PRL response to morphine was attenuated in adult rats. In addition, U50488 decreased median eminence dopamine synthesis in both adults and neonates. These findings suggest that the early developing, serotonin-independent opioid regulation of PRL is mediated through kappa-receptors, while the later-developing mechanism which requires intact serotonergic transmission works through mu-receptors. kappa-Receptors appear to regulate PRL secretion by directly inhibiting the activity of tuberoinfundibular dopamine neurons, while mu-receptors might regulate the tonic dopaminergic inhibition of PRL through a serotonergic pathway.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

December 15, 1987

Volume

465

Issue

1-2

Start / End Page

189 / 196

Location

Netherlands

Related Subject Headings

  • Serotonin
  • Receptors, Opioid, mu
  • Receptors, Opioid, kappa
  • Receptors, Opioid
  • Rats, Inbred Strains
  • Rats
  • Pyrrolidines
  • Prolactin
  • Peptide Fragments
  • Neurology & Neurosurgery
 

Citation

APA
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ICMJE
MLA
NLM
Bero, L. A., Lurie, S. N., & Kuhn, C. M. (1987). Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat. Brain Res, 465(1–2), 189–196. https://doi.org/10.1016/0165-3806(87)90240-9
Bero, L. A., S. N. Lurie, and C. M. Kuhn. “Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.Brain Res 465, no. 1–2 (December 15, 1987): 189–96. https://doi.org/10.1016/0165-3806(87)90240-9.
Bero LA, Lurie SN, Kuhn CM. Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat. Brain Res. 1987 Dec 15;465(1–2):189–96.
Bero, L. A., et al. “Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.Brain Res, vol. 465, no. 1–2, Dec. 1987, pp. 189–96. Pubmed, doi:10.1016/0165-3806(87)90240-9.
Bero LA, Lurie SN, Kuhn CM. Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat. Brain Res. 1987 Dec 15;465(1–2):189–196.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

December 15, 1987

Volume

465

Issue

1-2

Start / End Page

189 / 196

Location

Netherlands

Related Subject Headings

  • Serotonin
  • Receptors, Opioid, mu
  • Receptors, Opioid, kappa
  • Receptors, Opioid
  • Rats, Inbred Strains
  • Rats
  • Pyrrolidines
  • Prolactin
  • Peptide Fragments
  • Neurology & Neurosurgery