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α1-Adrenergic effects and liver regeneration

Publication ,  Journal Article
Cruise, JL; Knechtle, SJ; Bollinger, RR; Kuhn, C; Michalopoulos, G
Published in: Hepatology
1987

The effects of several treatments involving α-adrenergic mechanisms upon the early stages of rat liver regeneration were examined. Catecholamine concentrations in rat plasma were measured at various times after hepatectomy and were found to be elevated relative to those in plasma from sham-operated rats. Surgical hepatic denervation or injection of an α1-adrenergic receptor antagonist (prazosin) reduced incorporation of [3H] thymidine into liver DNA during the first 24 hr after partial hepatectomy. Chronic guanethidine injections (3 to 6 weeks) reduced liver catecholamine levels, but did not affect its ability to regenerate. The inhibition of regenerative DNA synthesis by prazosin was preceded by an alteration in the binding of epidermal growth factor to regenerating liver, which was apparently the result of an increased number of epidermal growth factor receptors. Thus, α1-adrenergic blockade, which affects both epidermal growth factor receptor binding and subsequent DNA synthesis in hepatocyte primary cultures, can also modulate these processes during liver regeneration in vivo.

Duke Scholars

Published In

Hepatology

Publication Date

1987

Volume

7

Issue

6

Start / End Page

1189 / 1194

Related Subject Headings

  • Gastroenterology & Hepatology
  • 1107 Immunology
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics
 

Citation

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Cruise, J. L., Knechtle, S. J., Bollinger, R. R., Kuhn, C., & Michalopoulos, G. (1987). α1-Adrenergic effects and liver regeneration. Hepatology, 7(6), 1189–1194.
Cruise, J. L., S. J. Knechtle, R. R. Bollinger, C. Kuhn, and G. Michalopoulos. “α1-Adrenergic effects and liver regeneration.” Hepatology 7, no. 6 (1987): 1189–94.
Cruise JL, Knechtle SJ, Bollinger RR, Kuhn C, Michalopoulos G. α1-Adrenergic effects and liver regeneration. Hepatology. 1987;7(6):1189–94.
Cruise, J. L., et al. “α1-Adrenergic effects and liver regeneration.” Hepatology, vol. 7, no. 6, 1987, pp. 1189–94.
Cruise JL, Knechtle SJ, Bollinger RR, Kuhn C, Michalopoulos G. α1-Adrenergic effects and liver regeneration. Hepatology. 1987;7(6):1189–1194.

Published In

Hepatology

Publication Date

1987

Volume

7

Issue

6

Start / End Page

1189 / 1194

Related Subject Headings

  • Gastroenterology & Hepatology
  • 1107 Immunology
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics