Skip to main content
Journal cover image

Ontogeny of endocrine responses to methadone in rats.

Publication ,  Journal Article
Kuhn, CM; Bartolome, MQ
Published in: Life Sci
April 25, 1983

The effects of methadone (METH) on serum levels of prolactin (PRL), growth hormone (GH), corticosterone (CS) and TSH were determined in developing rats. METH increased PRL, GH and CS and decreased TSH at all ages tested, but the time course and magnitude of these effects changed during ontogeny. METH effects on day 10 were lower in magnitude than those observed in adults. In 20 day old pups, METH effects on GH and CS were comparable to those of adults, but TSH effects were still blunted. METH effects on hormone secretion in both 10 and 20 day old pups lasted longer than those observed in adults. Naloxone blocked all hormonal responses in adults, but did not completely block METH effects on CS secretion in 10 day old pups.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

April 25, 1983

Volume

32

Issue

17

Start / End Page

1967 / 1974

Location

Netherlands

Related Subject Headings

  • Thyrotropin
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Pituitary Hormones
  • Pharmacology & Pharmacy
  • Naloxone
  • Methadone
  • Kinetics
  • Growth Hormone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kuhn, C. M., & Bartolome, M. Q. (1983). Ontogeny of endocrine responses to methadone in rats. Life Sci, 32(17), 1967–1974. https://doi.org/10.1016/0024-3205(83)90048-6
Kuhn, C. M., and M. Q. Bartolome. “Ontogeny of endocrine responses to methadone in rats.Life Sci 32, no. 17 (April 25, 1983): 1967–74. https://doi.org/10.1016/0024-3205(83)90048-6.
Kuhn CM, Bartolome MQ. Ontogeny of endocrine responses to methadone in rats. Life Sci. 1983 Apr 25;32(17):1967–74.
Kuhn, C. M., and M. Q. Bartolome. “Ontogeny of endocrine responses to methadone in rats.Life Sci, vol. 32, no. 17, Apr. 1983, pp. 1967–74. Pubmed, doi:10.1016/0024-3205(83)90048-6.
Kuhn CM, Bartolome MQ. Ontogeny of endocrine responses to methadone in rats. Life Sci. 1983 Apr 25;32(17):1967–1974.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

April 25, 1983

Volume

32

Issue

17

Start / End Page

1967 / 1974

Location

Netherlands

Related Subject Headings

  • Thyrotropin
  • Rats, Inbred Strains
  • Rats
  • Prolactin
  • Pituitary Hormones
  • Pharmacology & Pharmacy
  • Naloxone
  • Methadone
  • Kinetics
  • Growth Hormone