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Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat.

Publication ,  Journal Article
Grignolo, A; Kuhn, CM; Schanberg, SM
Published in: Life Sci
January 25, 1982

The effect of ovine growth hormone (GH) on kidney ornithine decarboxylase (ODC) was studied in newborn, preweanling and young adult rats. Basal kidney ODC activity was very low from 4 to 22 days after birth but rose 20-fold by day 25; it remained elevated through day 45. GH failed to stimulate ODC in the first two weeks after birth. GH did however stimulate ODC markedly from 20 through 45 days. Kidney ODC was stimulated in the neonate by vasopressin and by isoproterenol, but not by angiotensin II. Liver ODC remained relatively low and stable during development, and was responsive to GH at all ages studied. We conclude that a) the pattern of development of basal kidney ODC appears to be unique to this tissue and may be related to the postnatal maturation of renal morphology and/or function, b) neonatal kidney ODC is unresponsive to certain hormones but is not completely refractory to stimulation. These findings may have implications for the role of hormones in the maturation of the kidney and in the regulation of early renal function.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

January 25, 1982

Volume

30

Issue

4

Start / End Page

383 / 390

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Liver
  • Kidney
  • Growth Hormone
  • Carboxy-Lyases
  • Animals
  • Age Factors
 

Citation

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Grignolo, A., Kuhn, C. M., & Schanberg, S. M. (1982). Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat. Life Sci, 30(4), 383–390. https://doi.org/10.1016/0024-3205(82)90575-6
Grignolo, A., C. M. Kuhn, and S. M. Schanberg. “Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat.Life Sci 30, no. 4 (January 25, 1982): 383–90. https://doi.org/10.1016/0024-3205(82)90575-6.
Grignolo A, Kuhn CM, Schanberg SM. Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat. Life Sci. 1982 Jan 25;30(4):383–90.
Grignolo, A., et al. “Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat.Life Sci, vol. 30, no. 4, Jan. 1982, pp. 383–90. Pubmed, doi:10.1016/0024-3205(82)90575-6.
Grignolo A, Kuhn CM, Schanberg SM. Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat. Life Sci. 1982 Jan 25;30(4):383–390.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

January 25, 1982

Volume

30

Issue

4

Start / End Page

383 / 390

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Ornithine Decarboxylase
  • Liver
  • Kidney
  • Growth Hormone
  • Carboxy-Lyases
  • Animals
  • Age Factors