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Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats.

Publication ,  Journal Article
Kuhn, CM; Vogel, RA; Mailman, RB; Mueller, RA; Schanberg, SM; Breese, GR
Published in: Psychopharmacology (Berl)
1981

The intracisternal administration of 5,7-dihydroxytryptamine (5,7-DHT) to rats resulted in a potentiated response to 5-hydroxytryptophan (5-HTP) when the animals were tested 30 days later. The 5-HTP-induced changes include elevation of serum prolactin, decrease in operant responding, and the magnitude of the "serotonin behavioral syndrome" observed after 5-HTP administration. The serotonin concentration in brains of 5,7-DHT-treated animals reached maximum earlier and remained elevated longer than that of controls following administration of 5-HTP. Brain norepinephrine and dopamine concentration were not affected by 5-HTP in either group of animals. The increase in serum prolactin concentration elicited by administration of the serotonergic agonists quipazine or 5-methoxy-N,N-dimethyltryptamine and by the serotonin uptake inhibitor fenfluramine also was potentiated by pretreating rats with 5,7-DHT. These data suggest that both serotonergic receptor supersensitivity and the absence of presynaptic uptake sites contribute to the enhanced responses to 5-HTP occurring in rats previously treated with 5,7-DHT. The findings further demonstrate that both behavioral and hormonal measures can be used to assess the sensitivity of serotonergic receptors and indicate that 5,7-DHT may be useful in evaluating the role of serotonergic neurons in neuroendocrine function.

Duke Scholars

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1981

Volume

73

Issue

2

Start / End Page

188 / 193

Location

Germany

Related Subject Headings

  • Serotonin
  • Receptors, Serotonin
  • Rats
  • Quipazine
  • Psychiatry
  • Prolactin
  • Methoxydimethyltryptamines
  • Male
  • Fenfluramine
  • Dose-Response Relationship, Drug
 

Citation

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MLA
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Kuhn, C. M., Vogel, R. A., Mailman, R. B., Mueller, R. A., Schanberg, S. M., & Breese, G. R. (1981). Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology (Berl), 73(2), 188–193. https://doi.org/10.1007/BF00429216
Kuhn, C. M., R. A. Vogel, R. B. Mailman, R. A. Mueller, S. M. Schanberg, and G. R. Breese. “Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats.Psychopharmacology (Berl) 73, no. 2 (1981): 188–93. https://doi.org/10.1007/BF00429216.
Kuhn CM, Vogel RA, Mailman RB, Mueller RA, Schanberg SM, Breese GR. Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology (Berl). 1981;73(2):188–93.
Kuhn, C. M., et al. “Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats.Psychopharmacology (Berl), vol. 73, no. 2, 1981, pp. 188–93. Pubmed, doi:10.1007/BF00429216.
Kuhn CM, Vogel RA, Mailman RB, Mueller RA, Schanberg SM, Breese GR. Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats. Psychopharmacology (Berl). 1981;73(2):188–193.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1981

Volume

73

Issue

2

Start / End Page

188 / 193

Location

Germany

Related Subject Headings

  • Serotonin
  • Receptors, Serotonin
  • Rats
  • Quipazine
  • Psychiatry
  • Prolactin
  • Methoxydimethyltryptamines
  • Male
  • Fenfluramine
  • Dose-Response Relationship, Drug