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Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.

Publication ,  Journal Article
Breese, GR; Vogel, RA; Kuhn, CM; Mailman, RB; Mueller, RA; Schanberg, SM
Published in: Brain Res
October 27, 1978

The serotonin precursor, 5-hydroxytryptophan (5-HTP), can induce a behavioral syndrome characterized by rigidity, splayed feet, tremor, head weaving, salivation and forepaw treading. This response to 5-HTP was markedly potentiated in adult rats treated intracisternally with 5,7-dihydroxytryptamine (5,7-DHT) during development. Prevention of the 5,7-DHT-induced reduction of brain norepinephrine with pargyline or desipramine did not diminish the potentiation of 5-HTP, suggesting that noradrenergic fibers are not contributing to the altered 5-HTP response. It was also found that treatments with 5,7-DHT potentiated the release of prolactin and the disruption of responding in a fixed-ratio operant task induced by 5-HTP. Other experiments indicated that 5,7-DHT treatments potentiated 5-HTP without affecting the action of L-dihydroxyphenylalanine. In addition, administration of the decarboxylase inhibitor, R0-4-4602, at a dose that inhibits enzyme activity in brain, blocked the 5-HTP-induced behavioral syndrome in 5,7-DHT-treated rats, indicating that 5-HTP must be converted to serotonin for 5-HTP to alter behavior. Thus, the present studies indicate that destruction of serotonergic fibers during development can produce permanent changes in central serotonergic mechanisms.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

October 27, 1978

Volume

155

Issue

2

Start / End Page

263 / 275

Location

Netherlands

Related Subject Headings

  • Serotonin
  • Receptors, Serotonin
  • Receptors, Adrenergic
  • Rats
  • Prolactin
  • Premedication
  • Pregnancy
  • Pargyline
  • Norepinephrine
  • Neurology & Neurosurgery
 

Citation

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Breese, G. R., Vogel, R. A., Kuhn, C. M., Mailman, R. B., Mueller, R. A., & Schanberg, S. M. (1978). Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. Brain Res, 155(2), 263–275. https://doi.org/10.1016/0006-8993(78)91022-3
Breese, G. R., R. A. Vogel, C. M. Kuhn, R. B. Mailman, R. A. Mueller, and S. M. Schanberg. “Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.Brain Res 155, no. 2 (October 27, 1978): 263–75. https://doi.org/10.1016/0006-8993(78)91022-3.
Breese GR, Vogel RA, Kuhn CM, Mailman RB, Mueller RA, Schanberg SM. Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. Brain Res. 1978 Oct 27;155(2):263–75.
Breese, G. R., et al. “Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.Brain Res, vol. 155, no. 2, Oct. 1978, pp. 263–75. Pubmed, doi:10.1016/0006-8993(78)91022-3.
Breese GR, Vogel RA, Kuhn CM, Mailman RB, Mueller RA, Schanberg SM. Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. Brain Res. 1978 Oct 27;155(2):263–275.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

October 27, 1978

Volume

155

Issue

2

Start / End Page

263 / 275

Location

Netherlands

Related Subject Headings

  • Serotonin
  • Receptors, Serotonin
  • Receptors, Adrenergic
  • Rats
  • Prolactin
  • Premedication
  • Pregnancy
  • Pargyline
  • Norepinephrine
  • Neurology & Neurosurgery