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Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias.

Publication ,  Journal Article
Pritchett, EL; Lee, KL
Published in: J Clin Epidemiol
1988

Paroxysmal atrial tachycardia may be useful as a model for designing clinical trials of paroxysmal tachycardia. Individual occurrences of paroxysmal atrial tachycardia are clinically independent events, and the time periods between events follow an exponential probability distribution; i.e. paroxysmal atrial tachycardia behaves like a Poisson process. We propose that treatment of paroxysmal atrial tachycardia can be studied efficiently using a clinical trial with a two period cross-over design in which placebo and investigational therapy are delivered in random order. A screening phase, dose ranging phase, and both limbs of a cross-over plane can be completed in 180 days or less in each patient.

Duke Scholars

Published In

J Clin Epidemiol

DOI

ISSN

0895-4356

Publication Date

1988

Volume

41

Issue

9

Start / End Page

851 / 858

Location

United States

Related Subject Headings

  • Tachycardia, Supraventricular
  • Tachycardia, Paroxysmal
  • Research Design
  • Random Allocation
  • Humans
  • Epidemiology
  • Electrocardiography
  • Double-Blind Method
  • Clinical Trials as Topic
  • Anti-Arrhythmia Agents
 

Citation

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Pritchett, E. L., & Lee, K. L. (1988). Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias. J Clin Epidemiol, 41(9), 851–858. https://doi.org/10.1016/0895-4356(88)90101-1
Pritchett, E. L., and K. L. Lee. “Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias.J Clin Epidemiol 41, no. 9 (1988): 851–58. https://doi.org/10.1016/0895-4356(88)90101-1.
Pritchett, E. L., and K. L. Lee. “Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias.J Clin Epidemiol, vol. 41, no. 9, 1988, pp. 851–58. Pubmed, doi:10.1016/0895-4356(88)90101-1.
Pritchett EL, Lee KL. Designing clinical trials for paroxysmal atrial tachycardia and other paroxysmal arrhythmias. J Clin Epidemiol. 1988;41(9):851–858.
Journal cover image

Published In

J Clin Epidemiol

DOI

ISSN

0895-4356

Publication Date

1988

Volume

41

Issue

9

Start / End Page

851 / 858

Location

United States

Related Subject Headings

  • Tachycardia, Supraventricular
  • Tachycardia, Paroxysmal
  • Research Design
  • Random Allocation
  • Humans
  • Epidemiology
  • Electrocardiography
  • Double-Blind Method
  • Clinical Trials as Topic
  • Anti-Arrhythmia Agents