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Effects of long-term estrogen replacement therapy. II. Neoplasia.

Publication ,  Journal Article
Hammond, CB; Jelovsek, FR; Lee, KL; Creasman, WT; Parker, RT
Published in: Am J Obstet Gynecol
March 1, 1979

Two groups of hypoestrogenic women are analyzed by retrospective comparison. Patients were observed by a single group of physicians for at least five years -- 301 patients treated with replacement estrogen and 309 untreated patients. Of each group, 207 women had uteri in situ. Incidence figures for neoplasia (gynecologic, breast, and all sites) were compared between the two groups and with the Third National Cancer Survey, yielding a risk ratio for the development of adenocarcinoma of the endometrium among estrogen-treated women of 3.8 and 9.3, respectively. There was no increase among any other malignancies. The addition of synthetic progestin to estrogen therapy provided significant protection against the likelihood of developing endometrial cancer and did not reduce previously reported metabolic benefits of estrogen treatment. Data pertaining to estrogen use and details of the patients with endometrial carcinoma are presented.

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Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

March 1, 1979

Volume

133

Issue

5

Start / End Page

537 / 547

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Progestins
  • Obstetrics & Reproductive Medicine
  • North Carolina
  • Middle Aged
  • Humans
  • Genital Neoplasms, Female
  • Female
  • Estrogens, Conjugated (USP)
  • Estrogens
 

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Hammond, C. B., Jelovsek, F. R., Lee, K. L., Creasman, W. T., & Parker, R. T. (1979). Effects of long-term estrogen replacement therapy. II. Neoplasia. Am J Obstet Gynecol, 133(5), 537–547. https://doi.org/10.1016/0002-9378(79)90289-8
Hammond, C. B., F. R. Jelovsek, K. L. Lee, W. T. Creasman, and R. T. Parker. “Effects of long-term estrogen replacement therapy. II. Neoplasia.Am J Obstet Gynecol 133, no. 5 (March 1, 1979): 537–47. https://doi.org/10.1016/0002-9378(79)90289-8.
Hammond CB, Jelovsek FR, Lee KL, Creasman WT, Parker RT. Effects of long-term estrogen replacement therapy. II. Neoplasia. Am J Obstet Gynecol. 1979 Mar 1;133(5):537–47.
Hammond, C. B., et al. “Effects of long-term estrogen replacement therapy. II. Neoplasia.Am J Obstet Gynecol, vol. 133, no. 5, Mar. 1979, pp. 537–47. Pubmed, doi:10.1016/0002-9378(79)90289-8.
Hammond CB, Jelovsek FR, Lee KL, Creasman WT, Parker RT. Effects of long-term estrogen replacement therapy. II. Neoplasia. Am J Obstet Gynecol. 1979 Mar 1;133(5):537–547.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

March 1, 1979

Volume

133

Issue

5

Start / End Page

537 / 547

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Progestins
  • Obstetrics & Reproductive Medicine
  • North Carolina
  • Middle Aged
  • Humans
  • Genital Neoplasms, Female
  • Female
  • Estrogens, Conjugated (USP)
  • Estrogens