Skip to main content
Journal cover image

Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia.

Publication ,  Journal Article
Lyles, KW; Clark, AG; Drezner, MK
Published in: Calcif Tissue Int
March 1982

In order to determine whether a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia (XLH), we compared the serum 1,25-dihydroxyvitamin D [1,25(OH)2D] level in 52 normal subjects and 37 patients with XLH. In untreated patients, adults were found to have values similar to age-matched controls, while youths had values similar to growth-rate-matched controls but significantly lower than the levels of age-matched controls who were growing at a normal rate. In contrast, treated XLH patients of all ages had serum levels significantly lower than both controls and untreated XLH patients. Further, the serum levels of 1,25(OH)2D in these treated patients had a significant inverse linear correlation with serum 25-(OH)D concentrations. We propose that subjects with XLH have serum 1,25(OH)2D levels within appropriate age- and growth-rate-matched normal ranges. However, in the presence of hypophosphatemia, we would have anticipated elevated levels of 1,25(OH)2D; viewed in this light the serum 1,25(OH)2D levels are inadequate, suggesting the presence of a relative deficiency of this active vitamin D metabolite.

Duke Scholars

Published In

Calcif Tissue Int

DOI

ISSN

0171-967X

Publication Date

March 1982

Volume

34

Issue

2

Start / End Page

125 / 130

Location

United States

Related Subject Headings

  • X Chromosome
  • Sex Chromosomes
  • Osteomalacia
  • Middle Aged
  • Male
  • Hypophosphatemia, Familial
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lyles, K. W., Clark, A. G., & Drezner, M. K. (1982). Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Calcif Tissue Int, 34(2), 125–130. https://doi.org/10.1007/BF02411222
Lyles, K. W., A. G. Clark, and M. K. Drezner. “Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia.Calcif Tissue Int 34, no. 2 (March 1982): 125–30. https://doi.org/10.1007/BF02411222.
Lyles KW, Clark AG, Drezner MK. Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Calcif Tissue Int. 1982 Mar;34(2):125–30.
Lyles, K. W., et al. “Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia.Calcif Tissue Int, vol. 34, no. 2, Mar. 1982, pp. 125–30. Pubmed, doi:10.1007/BF02411222.
Lyles KW, Clark AG, Drezner MK. Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Calcif Tissue Int. 1982 Mar;34(2):125–130.
Journal cover image

Published In

Calcif Tissue Int

DOI

ISSN

0171-967X

Publication Date

March 1982

Volume

34

Issue

2

Start / End Page

125 / 130

Location

United States

Related Subject Headings

  • X Chromosome
  • Sex Chromosomes
  • Osteomalacia
  • Middle Aged
  • Male
  • Hypophosphatemia, Familial
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Child, Preschool