Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin.
Publication
, Journal Article
Fuchs, E; Marchuk, D
Published in: Proc Natl Acad Sci U S A
October 1983
We have traced the evolutionary origins of keratin-like sequences to the genomes of lower eukaryotes. The proteins encoded by these genes have evolved to form the intermediate filaments that comprise the backbone of vertebrate skin cells. Two related but distinct types of keratins encoded by two separate multigene subfamilies are expressed in the epidermal keratinocytes of vertebrate species from fish to human. Both at the level of protein and at the level of DNA, these two classes of keratins are coordinately conserved throughout vertebrate evolution, indicating the central role that both types of keratins must play in the assembly and structure of the 8-nm filament.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 1983
Volume
80
Issue
19
Start / End Page
5857 / 5861
Location
United States
Related Subject Headings
- Turtles
- Species Specificity
- Skin
- Saccharomyces cerevisiae
- Rats
- Ranidae
- Rabbits
- RNA, Messenger
- Mice
- Keratins
Citation
APA
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MLA
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Fuchs, E., & Marchuk, D. (1983). Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A, 80(19), 5857–5861. https://doi.org/10.1073/pnas.80.19.5857
Fuchs, E., and D. Marchuk. “Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin.” Proc Natl Acad Sci U S A 80, no. 19 (October 1983): 5857–61. https://doi.org/10.1073/pnas.80.19.5857.
Fuchs E, Marchuk D. Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A. 1983 Oct;80(19):5857–61.
Fuchs, E., and D. Marchuk. “Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin.” Proc Natl Acad Sci U S A, vol. 80, no. 19, Oct. 1983, pp. 5857–61. Pubmed, doi:10.1073/pnas.80.19.5857.
Fuchs E, Marchuk D. Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A. 1983 Oct;80(19):5857–5861.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 1983
Volume
80
Issue
19
Start / End Page
5857 / 5861
Location
United States
Related Subject Headings
- Turtles
- Species Specificity
- Skin
- Saccharomyces cerevisiae
- Rats
- Ranidae
- Rabbits
- RNA, Messenger
- Mice
- Keratins