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Overt Aggression and Psychotic Symptoms in Patients with Schizophrenia Treated with Clozapine, Olanzapine, Risperidone, or Haloperidol

Publication ,  Journal Article
Volavka, J; Czobor, P; Nolan, K; Sheitman, B; Lindenmayer, JP; Citrome, L; McEvoy, JP; Cooper, TB; Lieberman, JA
Published in: Journal of Clinical Psychopharmacology
2004

The subjects were 157 treatment-resistant inpatients diagnosed with chronic schizophrenia or schizoaffective disorder. They were randomly assigned to treatment with clozapine, olanzapine, risperidone, or haloperidol in a 14-week, double-blind trial. Incidents of overt aggression were recorded and their severity was scored. The Positive and Negative Syndrome Scale was administered. Atypical antipsychotics showed an overall superiority over haloperidol, particularly after the first 24 days of the study when the dose escalation of clozapine was completed. Once an adequate therapeutic dose of clozapine was reached, it was superior to haloperidol in reducing the number and severity of aggressive incidents. Patients exhibiting persistent aggressive behavior showed less improvement of psychotic symptoms than the other patients. There was an interaction between aggressiveness, medication type, and antipsychotic response: risperidone and olanzapine showed better antipsychotic efficacy in patients exhibiting less aggressive behavior; the opposite was true for clozapine. Clozapine appears to have superior antiaggresive effects in treatment-resistant patients; this superiority develops after the patient has been exposed to an adequate dose regimen.

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Published In

Journal of Clinical Psychopharmacology

DOI

ISSN

0271-0749

Publication Date

2004

Volume

24

Issue

2

Start / End Page

225 / 228

Related Subject Headings

  • Psychiatry
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

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Chicago
ICMJE
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Volavka, J., Czobor, P., Nolan, K., Sheitman, B., Lindenmayer, J. P., Citrome, L., … Lieberman, J. A. (2004). Overt Aggression and Psychotic Symptoms in Patients with Schizophrenia Treated with Clozapine, Olanzapine, Risperidone, or Haloperidol. Journal of Clinical Psychopharmacology, 24(2), 225–228. https://doi.org/10.1097/01.jcp.0000117424.05703.29
Volavka, J., P. Czobor, K. Nolan, B. Sheitman, J. P. Lindenmayer, L. Citrome, J. P. McEvoy, T. B. Cooper, and J. A. Lieberman. “Overt Aggression and Psychotic Symptoms in Patients with Schizophrenia Treated with Clozapine, Olanzapine, Risperidone, or Haloperidol.” Journal of Clinical Psychopharmacology 24, no. 2 (2004): 225–28. https://doi.org/10.1097/01.jcp.0000117424.05703.29.
Volavka J, Czobor P, Nolan K, Sheitman B, Lindenmayer JP, Citrome L, et al. Overt Aggression and Psychotic Symptoms in Patients with Schizophrenia Treated with Clozapine, Olanzapine, Risperidone, or Haloperidol. Journal of Clinical Psychopharmacology. 2004;24(2):225–8.
Volavka, J., et al. “Overt Aggression and Psychotic Symptoms in Patients with Schizophrenia Treated with Clozapine, Olanzapine, Risperidone, or Haloperidol.” Journal of Clinical Psychopharmacology, vol. 24, no. 2, 2004, pp. 225–28. Scival, doi:10.1097/01.jcp.0000117424.05703.29.
Volavka J, Czobor P, Nolan K, Sheitman B, Lindenmayer JP, Citrome L, McEvoy JP, Cooper TB, Lieberman JA. Overt Aggression and Psychotic Symptoms in Patients with Schizophrenia Treated with Clozapine, Olanzapine, Risperidone, or Haloperidol. Journal of Clinical Psychopharmacology. 2004;24(2):225–228.

Published In

Journal of Clinical Psychopharmacology

DOI

ISSN

0271-0749

Publication Date

2004

Volume

24

Issue

2

Start / End Page

225 / 228

Related Subject Headings

  • Psychiatry
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences