Conditional deletion of TrkC does not modify limbic epileptogenesis.
Publication
, Journal Article
Soren Leonard, A; Puranam, RS; Helgager, J; Liu, G; McNamara, JO
Published in: Epilepsy Res
November 2012
The neurotrophin receptor, tropomyosin-related kinase B (TrkB), is required for epileptogenesis in the kindling model. The role of a closely related neurotrophin receptor, TrkC, in limbic epileptogenesis is unknown. We examined limbic epileptogenesis in the kindling model in TrkC conditional null mice, using a strategy that previously established a critical role of TrkB. Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice. These findings reinforce the central role of TrkB as the principal neurotrophin receptor involved in limbic epileptogenesis.
Duke Scholars
Published In
Epilepsy Res
DOI
EISSN
1872-6844
Publication Date
November 2012
Volume
102
Issue
1-2
Start / End Page
126 / 130
Location
Netherlands
Related Subject Headings
- Receptor, trkC
- RNA, Messenger
- Protein-Tyrosine Kinases
- Neurology & Neurosurgery
- Mice, Knockout
- Mice
- Membrane Glycoproteins
- Limbic System
- Kindling, Neurologic
- Integrases
Citation
APA
Chicago
ICMJE
MLA
NLM
Soren Leonard, A., Puranam, R. S., Helgager, J., Liu, G., & McNamara, J. O. (2012). Conditional deletion of TrkC does not modify limbic epileptogenesis. Epilepsy Res, 102(1–2), 126–130. https://doi.org/10.1016/j.eplepsyres.2012.07.019
Soren Leonard, A., Ram S. Puranam, Jeffrey Helgager, Gumei Liu, and James O. McNamara. “Conditional deletion of TrkC does not modify limbic epileptogenesis.” Epilepsy Res 102, no. 1–2 (November 2012): 126–30. https://doi.org/10.1016/j.eplepsyres.2012.07.019.
Soren Leonard A, Puranam RS, Helgager J, Liu G, McNamara JO. Conditional deletion of TrkC does not modify limbic epileptogenesis. Epilepsy Res. 2012 Nov;102(1–2):126–30.
Soren Leonard, A., et al. “Conditional deletion of TrkC does not modify limbic epileptogenesis.” Epilepsy Res, vol. 102, no. 1–2, Nov. 2012, pp. 126–30. Pubmed, doi:10.1016/j.eplepsyres.2012.07.019.
Soren Leonard A, Puranam RS, Helgager J, Liu G, McNamara JO. Conditional deletion of TrkC does not modify limbic epileptogenesis. Epilepsy Res. 2012 Nov;102(1–2):126–130.
Published In
Epilepsy Res
DOI
EISSN
1872-6844
Publication Date
November 2012
Volume
102
Issue
1-2
Start / End Page
126 / 130
Location
Netherlands
Related Subject Headings
- Receptor, trkC
- RNA, Messenger
- Protein-Tyrosine Kinases
- Neurology & Neurosurgery
- Mice, Knockout
- Mice
- Membrane Glycoproteins
- Limbic System
- Kindling, Neurologic
- Integrases