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Intradentate colchicine retards the development of amygdala kindling.

Publication ,  Journal Article
Dasheiff, RM; McNamara, JO
Published in: Ann Neurol
April 1982

The mechanisms underlying the kindling model of epilepsy are unknown. Presumably, an altered network of neural circuits underlie amygdala kindling. Biochemical and radiohistochemical studies have pointed to the dentate granule cells (DGC) of the hippocampal formation as a member of this altered circuit. To test the role of these cells, colchicine, a neurotoxin of DGC, was directly injected into the dentate gyrus. Prior destruction of DGC retarded the development of amygdala kindling. Destruction of DGC after kindling was completed did not reverse the kindling effect. We conclude that DGC play a key role in the development, but not the permanence, of amygdala kindling. We propose a model whereby the greater the input to the hippocampal formation, the faster limbic kindling will proceed.

Duke Scholars

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

April 1982

Volume

11

Issue

4

Start / End Page

347 / 352

Location

United States

Related Subject Headings

  • Rats
  • Neurology & Neurosurgery
  • Kindling, Neurologic
  • Hippocampus
  • Epilepsy
  • Disease Models, Animal
  • Colchicine
  • Animals
  • Amygdala
  • 3209 Neurosciences
 

Citation

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ICMJE
MLA
NLM
Dasheiff, R. M., & McNamara, J. O. (1982). Intradentate colchicine retards the development of amygdala kindling. Ann Neurol, 11(4), 347–352. https://doi.org/10.1002/ana.410110405
Dasheiff, R. M., and J. O. McNamara. “Intradentate colchicine retards the development of amygdala kindling.Ann Neurol 11, no. 4 (April 1982): 347–52. https://doi.org/10.1002/ana.410110405.
Dasheiff RM, McNamara JO. Intradentate colchicine retards the development of amygdala kindling. Ann Neurol. 1982 Apr;11(4):347–52.
Dasheiff, R. M., and J. O. McNamara. “Intradentate colchicine retards the development of amygdala kindling.Ann Neurol, vol. 11, no. 4, Apr. 1982, pp. 347–52. Pubmed, doi:10.1002/ana.410110405.
Dasheiff RM, McNamara JO. Intradentate colchicine retards the development of amygdala kindling. Ann Neurol. 1982 Apr;11(4):347–352.
Journal cover image

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

April 1982

Volume

11

Issue

4

Start / End Page

347 / 352

Location

United States

Related Subject Headings

  • Rats
  • Neurology & Neurosurgery
  • Kindling, Neurologic
  • Hippocampus
  • Epilepsy
  • Disease Models, Animal
  • Colchicine
  • Animals
  • Amygdala
  • 3209 Neurosciences