Effects of oral choline on human complex partial seizures.
We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue, and (3) slight increase of seizure frequency. Both the patients and their families considered the patients much improved. No differences in any of these evaluations were noted in a fourth subject who had less of an increase (21%) of plasma choline content. The results suggest that oral choline therapy may be a useful adjunct in the treatment of intractable CPS. A blinded prospective study will be necessary to assess this possibility.
Duke Scholars
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- Neurology & Neurosurgery
- Male
- Humans
- Epilepsies, Partial
- Choline
- Adult
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
- 1109 Neurosciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neurology & Neurosurgery
- Male
- Humans
- Epilepsies, Partial
- Choline
- Adult
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
- 1109 Neurosciences