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Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein.

Publication ,  Journal Article
Staprans, SI; Barry, AP; Silvestri, G; Safrit, JT; Kozyr, N; Sumpter, B; Nguyen, H; McClure, H; Montefiori, D; Cohen, JI; Feinberg, MB
Published in: Proc Natl Acad Sci U S A
August 31, 2004

Given the dual role of CD4 T cells as both immune effectors and targets for HIV infection, the balance of CD4 versus CD8 T cell-mediated responses induced by candidate AIDS vaccines may be critical in determining postvaccination infection outcomes. An attenuated recombinant varicella-zoster virus vaccine expressing the simian immunodeficiency virus (SIV) envelope (Env) elicited nonneutralizing Env-binding antibodies and little if any cytotoxic T lymphocyte responses in rhesus macaques (Macaca mulatta). After challenge with SIV, Env vaccinees manifested increased levels of SIV replication, more rapid CD4 depletion, and accelerated progression to AIDS compared with controls. Enhanced SIV replication correlated with increased CD4 T cell proliferation soon after SIV challenge, apparently the result of an anamnestic response to SIV antigens. Thus activation of virus-specific CD4 T cells at the time of exposure to a CD4 T cell-tropic lentivirus, in the absence of an effective CD8 response, may enhance virus replication and disease. These data suggest suggest that candidate AIDS vaccines may not simply be either efficacious or neutral; they may also have the potential to be harmful.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

August 31, 2004

Volume

101

Issue

35

Start / End Page

13026 / 13031

Location

United States

Related Subject Headings

  • Virus Replication
  • Viral Envelope Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Macaca mulatta
  • CD4-Positive T-Lymphocytes
  • Antibody Formation
  • Animals
 

Citation

APA
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ICMJE
MLA
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Staprans, S. I., Barry, A. P., Silvestri, G., Safrit, J. T., Kozyr, N., Sumpter, B., … Feinberg, M. B. (2004). Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proc Natl Acad Sci U S A, 101(35), 13026–13031. https://doi.org/10.1073/pnas.0404739101
Staprans, Silvija I., Ashley P. Barry, Guido Silvestri, Jeffrey T. Safrit, Natalia Kozyr, Beth Sumpter, Hanh Nguyen, et al. “Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein.Proc Natl Acad Sci U S A 101, no. 35 (August 31, 2004): 13026–31. https://doi.org/10.1073/pnas.0404739101.
Staprans SI, Barry AP, Silvestri G, Safrit JT, Kozyr N, Sumpter B, et al. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13026–31.
Staprans, Silvija I., et al. “Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein.Proc Natl Acad Sci U S A, vol. 101, no. 35, Aug. 2004, pp. 13026–31. Pubmed, doi:10.1073/pnas.0404739101.
Staprans SI, Barry AP, Silvestri G, Safrit JT, Kozyr N, Sumpter B, Nguyen H, McClure H, Montefiori D, Cohen JI, Feinberg MB. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13026–13031.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

August 31, 2004

Volume

101

Issue

35

Start / End Page

13026 / 13031

Location

United States

Related Subject Headings

  • Virus Replication
  • Viral Envelope Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Macaca mulatta
  • CD4-Positive T-Lymphocytes
  • Antibody Formation
  • Animals