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Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.

Publication ,  Journal Article
Barouch, DH; Fu, TM; Montefiori, DC; Lewis, MG; Shiver, JW; Letvin, NL
Published in: Immunol Lett
November 1, 2001

Accumulating evidence has demonstrated the importance of cytotoxic T lymphocytes (CTLs) and helper T lymphocytes in controlling HIV-1 replication. We have elicited immune responses in rhesus monkeys utilizing DNA vaccines augmented by the administration of IL-2/Ig, a fusion protein consisting of interleukin-2 and the Fc portion of IgG2. These vaccine-elicited immune responses did not prevent infection following a high-dose intravenous challenge with SHIV(89.6P) but did control viremia to nearly undetectable levels and prevented immunodeficiency and clinical disease. In contrast, control monkeys developed high levels of viremia and exhibited a rapid loss of CD4(+) T cells, significant clinical disease progression, and death in half of the animals by day 140 following challenge. Vaccine approaches that elicit immune responses capable of reducing plasma viral loads, but not capable of inducing sterilizing immunity, may still provide substantial clinical benefits.

Duke Scholars

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

November 1, 2001

Volume

79

Issue

1-2

Start / End Page

57 / 61

Location

Netherlands

Related Subject Headings

  • Viremia
  • Vaccines, DNA
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Neutralization Tests
  • Macaca mulatta
 

Citation

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ICMJE
MLA
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Barouch, D. H., Fu, T. M., Montefiori, D. C., Lewis, M. G., Shiver, J. W., & Letvin, N. L. (2001). Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys. Immunol Lett, 79(1–2), 57–61. https://doi.org/10.1016/s0165-2478(01)00266-8
Barouch, D. H., T. M. Fu, D. C. Montefiori, M. G. Lewis, J. W. Shiver, and N. L. Letvin. “Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.Immunol Lett 79, no. 1–2 (November 1, 2001): 57–61. https://doi.org/10.1016/s0165-2478(01)00266-8.
Barouch DH, Fu TM, Montefiori DC, Lewis MG, Shiver JW, Letvin NL. Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys. Immunol Lett. 2001 Nov 1;79(1–2):57–61.
Barouch, D. H., et al. “Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.Immunol Lett, vol. 79, no. 1–2, Nov. 2001, pp. 57–61. Pubmed, doi:10.1016/s0165-2478(01)00266-8.
Barouch DH, Fu TM, Montefiori DC, Lewis MG, Shiver JW, Letvin NL. Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys. Immunol Lett. 2001 Nov 1;79(1–2):57–61.
Journal cover image

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

November 1, 2001

Volume

79

Issue

1-2

Start / End Page

57 / 61

Location

Netherlands

Related Subject Headings

  • Viremia
  • Vaccines, DNA
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Neutralization Tests
  • Macaca mulatta