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Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?

Publication ,  Journal Article
Hofmann-Lehmann, R; Rasmussen, RA; Vlasak, J; Smith, BA; Baba, TW; Liska, V; Montefiori, DC; McClure, HM; Anderson, DC; Bernacky, BJ; Rizvi, TA ...
Published in: J Med Primatol
August 2001

To develop immunoprophylaxis regimens against mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission, we established a simian-human immunodeficiency virus (SHIV) model in neonatal macaques that mimics intrapartum mucosal virus exposure (T.W. Baba, J. Koch, E.S. Mittler et al: AIDS Res Hum Retroviruses 10:351-357, 1994). We protected four neonates from oral SHIV-vpu+ challenge by ante- and postpartum treatment with a synergistic triple combination of immunoglobulin (Ig) G1 human anti-HIV-1 neutralizing monoclonal antibodies (mAbs) (T.W. Baba, V. Liska, R. Hofmann-Lehmann et al: Nature Med 6:200-206, 2000), which recognize the CD4-binding site of Env, a glycosylation-dependent gp120, or a linear gp41 epitope. Two neonates that received only postpartum mAbs were also protected from oral SHIV-vpu+ challenge, indicating that postpartum treatment alone is sufficient. Next, we evaluated a similar mAb combination against SHIV89.6P, which encodes env of primary HIV89.6. One of four mAb-treated neonates was protected from infection and two maintained normal CD4+ T-cell counts. We conclude that the epitopes recognized by the three mAbs are important determinants for achieving protection. Combination immunoprophylaxis with synergistic mAbs seems promising to prevent maternal HIV-1 transmission in humans.

Duke Scholars

Published In

J Med Primatol

DOI

ISSN

0047-2565

Publication Date

August 2001

Volume

30

Issue

4

Start / End Page

190 / 196

Location

Denmark

Related Subject Headings

  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Pregnancy
  • Postpartum Period
  • Male
  • Macaca mulatta
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
  • Immunoglobulin G
 

Citation

APA
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ICMJE
MLA
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Hofmann-Lehmann, R., Rasmussen, R. A., Vlasak, J., Smith, B. A., Baba, T. W., Liska, V., … Ruprecht, R. M. (2001). Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission? J Med Primatol, 30(4), 190–196. https://doi.org/10.1034/j.1600-0684.2001.d01-52.x
Hofmann-Lehmann, R., R. A. Rasmussen, J. Vlasak, B. A. Smith, T. W. Baba, V. Liska, D. C. Montefiori, et al. “Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?J Med Primatol 30, no. 4 (August 2001): 190–96. https://doi.org/10.1034/j.1600-0684.2001.d01-52.x.
Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, et al. Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission? J Med Primatol. 2001 Aug;30(4):190–6.
Hofmann-Lehmann, R., et al. “Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?J Med Primatol, vol. 30, no. 4, Aug. 2001, pp. 190–96. Pubmed, doi:10.1034/j.1600-0684.2001.d01-52.x.
Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Posner MR, Cavacini LA, Chou TC, Ruprecht RM. Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission? J Med Primatol. 2001 Aug;30(4):190–196.
Journal cover image

Published In

J Med Primatol

DOI

ISSN

0047-2565

Publication Date

August 2001

Volume

30

Issue

4

Start / End Page

190 / 196

Location

Denmark

Related Subject Headings

  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Pregnancy
  • Postpartum Period
  • Male
  • Macaca mulatta
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
  • Immunoglobulin G