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Mutation and evolution of microsatellites in Drosophila melanogaster.

Publication ,  Journal Article
Schug, MD; Hutter, CM; Noor, MA; Aquadro, CF
Published in: Genetica
January 1998

Levels of nucleotide polymorphism in the Drosophila melanogaster genome are correlated with rates of recombination. This relationship may be due to hitchhiking of advantageous mutations (selective sweeps) or to continual removal of deleterious mutations from the genome (background selection). One test of the relative contributions of selective sweeps and background selection to the observed levels of variation in the genome of D. melanogaster is to compare levels of nucleotide variability (with a mutation rate on the order of 10(-9) per nucleotide per generation) with more rapidly evolving DNA loci such as microsatellites. This test depends critically on details of the mutational process of microsatellites. In this paper, we summarize our studies of microsatellite characteristics and mutation rates in D. melanogaster. We find that D. melanogaster microsatellites are short and have a mutation rate (6.5 x 10(-6) per locus per generation) several orders of magnitude lower than mammals studied to date. We further show that genetic variation at 18 dinucleotide repeat microsatellites in a population of D. melanogaster from Maryland is correlated with regional rates of recombination. These and other microsatellite data suggest that both background selection and selective sweeps may contribute to the correlation between DNA sequence variation and recombination in Drosophila.

Duke Scholars

Published In

Genetica

DOI

EISSN

1573-6857

ISSN

0016-6707

Publication Date

January 1998

Volume

102-103

Issue

1-6

Start / End Page

359 / 367

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Sequence Alignment
  • Recombination, Genetic
  • Polymorphism, Genetic
  • Mutation
  • Molecular Sequence Data
  • Microsatellite Repeats
  • Genetic Variation
  • Evolutionary Biology
  • Evolution, Molecular
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schug, M. D., Hutter, C. M., Noor, M. A., & Aquadro, C. F. (1998). Mutation and evolution of microsatellites in Drosophila melanogaster. Genetica, 102103(1–6), 359–367. https://doi.org/10.1023/a:1017083025154
Schug, M. D., C. M. Hutter, M. A. Noor, and C. F. Aquadro. “Mutation and evolution of microsatellites in Drosophila melanogaster.Genetica 102–103, no. 1–6 (January 1998): 359–67. https://doi.org/10.1023/a:1017083025154.
Schug MD, Hutter CM, Noor MA, Aquadro CF. Mutation and evolution of microsatellites in Drosophila melanogaster. Genetica. 1998 Jan;102–103(1–6):359–67.
Schug, M. D., et al. “Mutation and evolution of microsatellites in Drosophila melanogaster.Genetica, vol. 102–103, no. 1–6, Jan. 1998, pp. 359–67. Epmc, doi:10.1023/a:1017083025154.
Schug MD, Hutter CM, Noor MA, Aquadro CF. Mutation and evolution of microsatellites in Drosophila melanogaster. Genetica. 1998 Jan;102–103(1–6):359–367.
Journal cover image

Published In

Genetica

DOI

EISSN

1573-6857

ISSN

0016-6707

Publication Date

January 1998

Volume

102-103

Issue

1-6

Start / End Page

359 / 367

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Sequence Alignment
  • Recombination, Genetic
  • Polymorphism, Genetic
  • Mutation
  • Molecular Sequence Data
  • Microsatellite Repeats
  • Genetic Variation
  • Evolutionary Biology
  • Evolution, Molecular