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In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.

Publication ,  Journal Article
Del Poeta, M; Bixel, AS; Barchiesi, F; Tidwell, RR; Boykin, D; Scalise, G; Perfect, JR
Published in: J Antimicrob Chemother
August 1999

We investigated the in-vitro activity of three selected dicationic aromatic compounds for nine clinical isolates of Cryptococcus neoformans and 93 clinical isolates of Candida spp., representing 12 different species, using a broth macrodilution method following NCCLS recommendations. All the clinical isolates were also tested for fluconazole susceptibility. The in-vitro data demonstrate that compounds 39 and 57 have excellent in-vitro activity for all tested strains (MIC 0.19-1.56 mg/L) except Candida pelliculosa. Moreover, compound 39 showed excellent in-vitro fungicidal activity against Candida krusei, Candida glabrata, Candida lusitaniae and Cryptococcus neoformans with MFCs in the range 0.39-6.25 mg/L. Both compounds 39 and 57 showed excellent in-vitro activity against fluconazole-resistant Candida albicans isolates, including a C. albicans strain that contains all known fluconazole-resistant mechanisms. Comparing MIC data from compounds 21, 39 and 57 with fluconazole, we found a statistically significant difference only with compound 39 (P = 0.043). However, comparing MFC data from compounds 21, 39 and 57 with fluconazole, we found statistically significant differences with all three compounds (P < 0.00001). These data indicate the potential antifungal breadth of two bis-benzimidazoles (compounds 39 and 57) as antifungal agents against yeasts. If it can be determined that compounds 39 and 57 are effective and non-toxic in vivo, the prospect of these compounds as clinically useful antifungal agents will be enhanced.

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Published In

J Antimicrob Chemother

DOI

ISSN

0305-7453

Publication Date

August 1999

Volume

44

Issue

2

Start / End Page

223 / 228

Location

England

Related Subject Headings

  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Furans
  • Fluconazole
  • Drug Resistance, Microbial
  • Cryptococcus neoformans
  • Cryptococcosis
  • Candidiasis
  • Candida
 

Citation

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ICMJE
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Del Poeta, M., Bixel, A. S., Barchiesi, F., Tidwell, R. R., Boykin, D., Scalise, G., & Perfect, J. R. (1999). In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp. J Antimicrob Chemother, 44(2), 223–228. https://doi.org/10.1093/jac/44.2.223
Del Poeta, M., A. S. Bixel, F. Barchiesi, R. R. Tidwell, D. Boykin, G. Scalise, and J. R. Perfect. “In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.J Antimicrob Chemother 44, no. 2 (August 1999): 223–28. https://doi.org/10.1093/jac/44.2.223.
Del Poeta M, Bixel AS, Barchiesi F, Tidwell RR, Boykin D, Scalise G, et al. In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp. J Antimicrob Chemother. 1999 Aug;44(2):223–8.
Del Poeta, M., et al. “In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.J Antimicrob Chemother, vol. 44, no. 2, Aug. 1999, pp. 223–28. Pubmed, doi:10.1093/jac/44.2.223.
Del Poeta M, Bixel AS, Barchiesi F, Tidwell RR, Boykin D, Scalise G, Perfect JR. In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp. J Antimicrob Chemother. 1999 Aug;44(2):223–228.
Journal cover image

Published In

J Antimicrob Chemother

DOI

ISSN

0305-7453

Publication Date

August 1999

Volume

44

Issue

2

Start / End Page

223 / 228

Location

England

Related Subject Headings

  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Furans
  • Fluconazole
  • Drug Resistance, Microbial
  • Cryptococcus neoformans
  • Cryptococcosis
  • Candidiasis
  • Candida