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Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.

Publication ,  Journal Article
Perfect, JR; Wright, KA
Published in: J Antimicrob Chemother
January 1994

In the quest for safer and more effective antifungal agents, amphotericin B (AMB) has been placed in a variety of lipid preparations. In this study, we examined the efficacy of amphotericin B lipid complex (ABLC) on experimental cryptococcal meningitis and disseminated candidosis. This formulation is relatively safe compared to the parent compound, and therefore doses ten times greater than the commercial amphotericin B deoxycholate can be given to rabbits. Although at equal doses the ABLC preparation is less potent than AMB, a higher dose of ABLC was rapidly fungicidal in the contexts of both a central nervous system infection with Cryptococcus neoformans during immune suppression, and a heart and kidney infection with Candida albicans. Rapid sterilization of tissue should be a goal of antifungal drug therapy, particularly in the immune compromised host. From these studies, this AMB lipid formulation has the ability to produce rapid fungicidal activity in vivo, but it requires higher doses than AMB deoxycholate. Clinical trials in humans must examine carefully the therapeutic-toxic ratio in dose-escalation protocols to determine the optimal dosage strategy for this agent.

Duke Scholars

Published In

J Antimicrob Chemother

DOI

ISSN

0305-7453

Publication Date

January 1994

Volume

33

Issue

1

Start / End Page

73 / 81

Location

England

Related Subject Headings

  • Rabbits
  • Microbiology
  • Meningitis, Cryptococcal
  • Male
  • Liposomes
  • Kidney
  • Endocarditis
  • Drug Combinations
  • Deoxycholic Acid
  • Cryptococcus neoformans
 

Citation

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Perfect, J. R., & Wright, K. A. (1994). Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis. J Antimicrob Chemother, 33(1), 73–81. https://doi.org/10.1093/jac/33.1.73
Perfect, J. R., and K. A. Wright. “Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.J Antimicrob Chemother 33, no. 1 (January 1994): 73–81. https://doi.org/10.1093/jac/33.1.73.
Perfect, J. R., and K. A. Wright. “Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.J Antimicrob Chemother, vol. 33, no. 1, Jan. 1994, pp. 73–81. Pubmed, doi:10.1093/jac/33.1.73.
Journal cover image

Published In

J Antimicrob Chemother

DOI

ISSN

0305-7453

Publication Date

January 1994

Volume

33

Issue

1

Start / End Page

73 / 81

Location

England

Related Subject Headings

  • Rabbits
  • Microbiology
  • Meningitis, Cryptococcal
  • Male
  • Liposomes
  • Kidney
  • Endocarditis
  • Drug Combinations
  • Deoxycholic Acid
  • Cryptococcus neoformans