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Hemodynamic effects of the antiarrhythmic drug pirmenol.

Publication ,  Journal Article
Phillips, HR; Stack, RS; Davis, DD; Morris, KG; Lee, KL; Shand, DG; Pritchett, EL
Published in: Clin Pharmacol Ther
August 1982

We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patients with coronary artery disease who were undergoing routine diagnostic cardiac catheterization. Pirmenol was given as a 50-mg IV injection over 2 min followed by a constant infusion of 2.5 mg/min for up to 36 min. Plasma pirmenol levels were within or near the previously determined therapeutic range in all patients. There were no significant changes in systolic blood pressure or cardiac output. Diastolic blood pressure rose from a mean (+/- SD) 78 +/- 7 during the control period to 82 +/- 6 during the infusion, heart rate rose from 66 +/- 6 during the control period to 75 +/- 7 during infusion and ejection fraction fell from 60 +/- 8 during control to 55 +/- 12 during infusion. Although the left ventricular end-diastolic pressure rose from 6 +/- 2 during control to 8 +/- 3 during the infusion, the left ventricular stroke work index fell and the left ventricular work index per minute did not change. The fall in ejection fraction did not correlate with the control ejection fraction, plasma pirmenol levels, or the change in heart rate. The decline in ejection fraction and the failure of the left ventricular work index per minute to rise despite a small rise in left ventricular end-diastolic pressure may indicate a potential myocardial depressant effect of pirmenol.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

August 1982

Volume

32

Issue

2

Start / End Page

235 / 239

Location

United States

Related Subject Headings

  • Piperidines
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Injections, Intravenous
  • Humans
  • Hemodynamics
  • Drug Evaluation
  • Anti-Arrhythmia Agents
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Phillips, H. R., Stack, R. S., Davis, D. D., Morris, K. G., Lee, K. L., Shand, D. G., & Pritchett, E. L. (1982). Hemodynamic effects of the antiarrhythmic drug pirmenol. Clin Pharmacol Ther, 32(2), 235–239. https://doi.org/10.1038/clpt.1982.153
Phillips, H. R., R. S. Stack, D. D. Davis, K. G. Morris, K. L. Lee, D. G. Shand, and E. L. Pritchett. “Hemodynamic effects of the antiarrhythmic drug pirmenol.Clin Pharmacol Ther 32, no. 2 (August 1982): 235–39. https://doi.org/10.1038/clpt.1982.153.
Phillips HR, Stack RS, Davis DD, Morris KG, Lee KL, Shand DG, et al. Hemodynamic effects of the antiarrhythmic drug pirmenol. Clin Pharmacol Ther. 1982 Aug;32(2):235–9.
Phillips, H. R., et al. “Hemodynamic effects of the antiarrhythmic drug pirmenol.Clin Pharmacol Ther, vol. 32, no. 2, Aug. 1982, pp. 235–39. Pubmed, doi:10.1038/clpt.1982.153.
Phillips HR, Stack RS, Davis DD, Morris KG, Lee KL, Shand DG, Pritchett EL. Hemodynamic effects of the antiarrhythmic drug pirmenol. Clin Pharmacol Ther. 1982 Aug;32(2):235–239.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

August 1982

Volume

32

Issue

2

Start / End Page

235 / 239

Location

United States

Related Subject Headings

  • Piperidines
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Injections, Intravenous
  • Humans
  • Hemodynamics
  • Drug Evaluation
  • Anti-Arrhythmia Agents
  • 3214 Pharmacology and pharmaceutical sciences