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Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker?

Publication ,  Journal Article
Overstreet, DH; Janowsky, DS; Rezvani, AH
Published in: Alcohol Alcohol
1989

There is an overlap between alcoholism and depressive disorders. However, alcoholics tend to be resistant to the effect of cholinergic agonists, whereas depressives tend to be more sensitive. A recently developed animal model of depression which is more sensitive to cholinergic agonists is also more sensitive to the acute effects of ethanol. These consistent human and animal studies suggest that cholinergic challenges may be helpful in separating alcoholics from depressives.

Duke Scholars

Published In

Alcohol Alcohol

ISSN

0735-0414

Publication Date

1989

Volume

24

Issue

3

Start / End Page

253 / 255

Location

England

Related Subject Headings

  • Substance Abuse
  • Sleep, REM
  • Receptors, Cholinergic
  • Reaction Time
  • Physostigmine
  • Humans
  • Evoked Potentials, Auditory
  • Depressive Disorder
  • Cholinergic Fibers
  • Brain
 

Citation

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ICMJE
MLA
NLM
Overstreet, D. H., Janowsky, D. S., & Rezvani, A. H. (1989). Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker? Alcohol Alcohol, 24(3), 253–255.
Overstreet, D. H., D. S. Janowsky, and A. H. Rezvani. “Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker?Alcohol Alcohol 24, no. 3 (1989): 253–55.
Overstreet DH, Janowsky DS, Rezvani AH. Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker? Alcohol Alcohol. 1989;24(3):253–5.
Overstreet, D. H., et al. “Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker?Alcohol Alcohol, vol. 24, no. 3, 1989, pp. 253–55.
Overstreet DH, Janowsky DS, Rezvani AH. Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker? Alcohol Alcohol. 1989;24(3):253–255.
Journal cover image

Published In

Alcohol Alcohol

ISSN

0735-0414

Publication Date

1989

Volume

24

Issue

3

Start / End Page

253 / 255

Location

England

Related Subject Headings

  • Substance Abuse
  • Sleep, REM
  • Receptors, Cholinergic
  • Reaction Time
  • Physostigmine
  • Humans
  • Evoked Potentials, Auditory
  • Depressive Disorder
  • Cholinergic Fibers
  • Brain