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Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells.

Publication ,  Journal Article
Brier, AM; Snyderman, R; Mergenhagen, SE; Notkins, AL
Published in: Science
December 4, 1970

Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 4, 1970

Volume

170

Issue

3962

Start / End Page

1104 / 1106

Location

United States

Related Subject Headings

  • Virus Cultivation
  • Simplexvirus
  • Rabbits
  • Leukocytes
  • Inflammation
  • Guinea Pigs
  • General Science & Technology
  • Culture Techniques
  • Culture Media
  • Complement System Proteins
 

Citation

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ICMJE
MLA
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Brier, A. M., Snyderman, R., Mergenhagen, S. E., & Notkins, A. L. (1970). Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. Science, 170(3962), 1104–1106. https://doi.org/10.1126/science.170.3962.1104
Brier, A. M., R. Snyderman, S. E. Mergenhagen, and A. L. Notkins. “Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells.Science 170, no. 3962 (December 4, 1970): 1104–6. https://doi.org/10.1126/science.170.3962.1104.
Brier AM, Snyderman R, Mergenhagen SE, Notkins AL. Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. Science. 1970 Dec 4;170(3962):1104–6.
Brier, A. M., et al. “Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells.Science, vol. 170, no. 3962, Dec. 1970, pp. 1104–06. Pubmed, doi:10.1126/science.170.3962.1104.
Brier AM, Snyderman R, Mergenhagen SE, Notkins AL. Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. Science. 1970 Dec 4;170(3962):1104–1106.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 4, 1970

Volume

170

Issue

3962

Start / End Page

1104 / 1106

Location

United States

Related Subject Headings

  • Virus Cultivation
  • Simplexvirus
  • Rabbits
  • Leukocytes
  • Inflammation
  • Guinea Pigs
  • General Science & Technology
  • Culture Techniques
  • Culture Media
  • Complement System Proteins