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Rat myoblast fusion requires metalloendoprotease activity.

Publication ,  Journal Article
Couch, CB; Strittmatter, WJ
Published in: Cell
January 1983

The calcium-dependent fusion of cultured rat myoblasts to multinucleate myotubes appears to require the activity of a neutral metalloendoprotease at the time of fusion. Metalloendoprotease inhibitors and synthetic dipeptide substrates prevent myoblast fusion when added to fusion-competent myoblasts with the addition of calcium. Metalloendoprotease activity has been identified and partially characterized in myoblast membranes with a fluorogenic protease substrate, and is inhibited by the same compounds that prevent fusion.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

January 1983

Volume

32

Issue

1

Start / End Page

257 / 265

Location

United States

Related Subject Headings

  • Rats
  • Protease Inhibitors
  • Muscles
  • Metalloendopeptidases
  • Developmental Biology
  • Cells, Cultured
  • Cell Fusion
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Couch, C. B., & Strittmatter, W. J. (1983). Rat myoblast fusion requires metalloendoprotease activity. Cell, 32(1), 257–265. https://doi.org/10.1016/0092-8674(83)90516-0
Couch, C. B., and W. J. Strittmatter. “Rat myoblast fusion requires metalloendoprotease activity.Cell 32, no. 1 (January 1983): 257–65. https://doi.org/10.1016/0092-8674(83)90516-0.
Couch CB, Strittmatter WJ. Rat myoblast fusion requires metalloendoprotease activity. Cell. 1983 Jan;32(1):257–65.
Couch, C. B., and W. J. Strittmatter. “Rat myoblast fusion requires metalloendoprotease activity.Cell, vol. 32, no. 1, Jan. 1983, pp. 257–65. Pubmed, doi:10.1016/0092-8674(83)90516-0.
Couch CB, Strittmatter WJ. Rat myoblast fusion requires metalloendoprotease activity. Cell. 1983 Jan;32(1):257–265.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

January 1983

Volume

32

Issue

1

Start / End Page

257 / 265

Location

United States

Related Subject Headings

  • Rats
  • Protease Inhibitors
  • Muscles
  • Metalloendopeptidases
  • Developmental Biology
  • Cells, Cultured
  • Cell Fusion
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences