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Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease.

Publication ,  Journal Article
Ralph, DD; Springmeyer, SC; Sullivan, KM; Hackman, RC; Storb, R; Thomas, ED
Published in: Am Rev Respir Dis
April 1984

Severe obstructive airways disease developed in 4 young nonsmoking adults after marrow transplantation. They were free of respiratory disease until symptoms developed 277 to 600 days after transplant. Pulmonary function testing showed that the mean forced expiratory volume in one second was 35% of predicted (range, 23 to 49%). All patients had active or inactive extensive chronic graft-versus-host disease that included oral mucositis, esophagitis, sinusitis, and oral and ocular sicca. Three patients had subnormal serum IgA levels. Bronchitis was apparent during fiberoptic bronchoscopy in 3 patients. An open-lung biopsy specimen from 1 patient showed obliterative bronchiolitis. Treatment has included bronchodilators and corticosteroids without objective benefit. The disorder stabilized in all 4 patients, but a severe reduction in air flow persisted. Awareness of this complication may lead to earlier diagnosis and more effective treatment.

Duke Scholars

Published In

Am Rev Respir Dis

ISSN

0003-0805

Publication Date

April 1984

Volume

129

Issue

4

Start / End Page

641 / 644

Location

United States

Related Subject Headings

  • Male
  • Lung
  • Humans
  • Graft vs Host Disease
  • Female
  • Bronchopneumonia
  • Bone Marrow Transplantation
  • Airway Obstruction
  • Adult
  • Adolescent
 

Citation

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Ralph, D. D., Springmeyer, S. C., Sullivan, K. M., Hackman, R. C., Storb, R., & Thomas, E. D. (1984). Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease. Am Rev Respir Dis, 129(4), 641–644.
Ralph, D. D., S. C. Springmeyer, K. M. Sullivan, R. C. Hackman, R. Storb, and E. D. Thomas. “Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease.Am Rev Respir Dis 129, no. 4 (April 1984): 641–44.
Ralph DD, Springmeyer SC, Sullivan KM, Hackman RC, Storb R, Thomas ED. Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease. Am Rev Respir Dis. 1984 Apr;129(4):641–4.
Ralph DD, Springmeyer SC, Sullivan KM, Hackman RC, Storb R, Thomas ED. Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease. Am Rev Respir Dis. 1984 Apr;129(4):641–644.

Published In

Am Rev Respir Dis

ISSN

0003-0805

Publication Date

April 1984

Volume

129

Issue

4

Start / End Page

641 / 644

Location

United States

Related Subject Headings

  • Male
  • Lung
  • Humans
  • Graft vs Host Disease
  • Female
  • Bronchopneumonia
  • Bone Marrow Transplantation
  • Airway Obstruction
  • Adult
  • Adolescent