Cancer gene detection using surface-enhanced Raman scattering (SERS)
Publication
, Journal Article
Vo-Dinh, T; Allain, LR; Stokes, DL
Published in: Journal of Raman Spectroscopy
January 1, 2002
We describe the development of a surface-enhanced Raman scattering (SERS) method for cancer gene detection. The technology uses DNA gene probes based on SERS labels for gene detection. The detection method uses nanostructured metallic substrates as SERS-active platforms. The surface-enhanced Raman gene (SERGen) probes can be used to detect DNA targets via hybridization to DNA sequences complementary to these probes. The probes do not require the use of radioactive labels and have great potential to provide both sensitivity and selectivity. The usefulness of the SERGen approach and its applications in cancer gene diagnostics (e.g. BRCA1 breast cancer gene and BAX gene) is discussed. © 2002 John Wiley & Sons, Ltd.
Duke Scholars
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Published In
Journal of Raman Spectroscopy
DOI
ISSN
0377-0486
Publication Date
January 1, 2002
Volume
33
Issue
7
Start / End Page
511 / 516
Related Subject Headings
- Chemical Physics
- 5104 Condensed matter physics
- 3406 Physical chemistry
- 3402 Inorganic chemistry
- 0913 Mechanical Engineering
- 0306 Physical Chemistry (incl. Structural)
- 0204 Condensed Matter Physics
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Vo-Dinh, T., Allain, L. R., & Stokes, D. L. (2002). Cancer gene detection using surface-enhanced Raman scattering (SERS). Journal of Raman Spectroscopy, 33(7), 511–516. https://doi.org/10.1002/jrs.883
Vo-Dinh, T., L. R. Allain, and D. L. Stokes. “Cancer gene detection using surface-enhanced Raman scattering (SERS).” Journal of Raman Spectroscopy 33, no. 7 (January 1, 2002): 511–16. https://doi.org/10.1002/jrs.883.
Vo-Dinh T, Allain LR, Stokes DL. Cancer gene detection using surface-enhanced Raman scattering (SERS). Journal of Raman Spectroscopy. 2002 Jan 1;33(7):511–6.
Vo-Dinh, T., et al. “Cancer gene detection using surface-enhanced Raman scattering (SERS).” Journal of Raman Spectroscopy, vol. 33, no. 7, Jan. 2002, pp. 511–16. Scopus, doi:10.1002/jrs.883.
Vo-Dinh T, Allain LR, Stokes DL. Cancer gene detection using surface-enhanced Raman scattering (SERS). Journal of Raman Spectroscopy. 2002 Jan 1;33(7):511–516.
Published In
Journal of Raman Spectroscopy
DOI
ISSN
0377-0486
Publication Date
January 1, 2002
Volume
33
Issue
7
Start / End Page
511 / 516
Related Subject Headings
- Chemical Physics
- 5104 Condensed matter physics
- 3406 Physical chemistry
- 3402 Inorganic chemistry
- 0913 Mechanical Engineering
- 0306 Physical Chemistry (incl. Structural)
- 0204 Condensed Matter Physics