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Monoclonal B cell lymphocytosis: clinical and population perspectives.

Publication ,  Journal Article
Caporaso, NE; Marti, GE; Landgren, O; Azzato, E; Weinberg, JB; Goldin, L; Shanafelt, T
Published in: Cytometry B Clin Cytom
2010

Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression.

Duke Scholars

Published In

Cytometry B Clin Cytom

DOI

EISSN

1552-4957

Publication Date

2010

Volume

78 Suppl 1

Issue

Suppl 1

Start / End Page

S115 / S119

Location

United States

Related Subject Headings

  • Tissue Donors
  • Risk Factors
  • Lymphocytosis
  • Lymphocyte Count
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Immunology
  • Humans
  • Disease Progression
  • Clone Cells
  • Bone Marrow Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Caporaso, N. E., Marti, G. E., Landgren, O., Azzato, E., Weinberg, J. B., Goldin, L., & Shanafelt, T. (2010). Monoclonal B cell lymphocytosis: clinical and population perspectives. Cytometry B Clin Cytom, 78 Suppl 1(Suppl 1), S115–S119. https://doi.org/10.1002/cyto.b.20555
Caporaso, Neil E., Gerald E. Marti, Ola Landgren, Elizabeth Azzato, J Brice Weinberg, Lynn Goldin, and Tait Shanafelt. “Monoclonal B cell lymphocytosis: clinical and population perspectives.Cytometry B Clin Cytom 78 Suppl 1, no. Suppl 1 (2010): S115–19. https://doi.org/10.1002/cyto.b.20555.
Caporaso NE, Marti GE, Landgren O, Azzato E, Weinberg JB, Goldin L, et al. Monoclonal B cell lymphocytosis: clinical and population perspectives. Cytometry B Clin Cytom. 2010;78 Suppl 1(Suppl 1):S115–9.
Caporaso, Neil E., et al. “Monoclonal B cell lymphocytosis: clinical and population perspectives.Cytometry B Clin Cytom, vol. 78 Suppl 1, no. Suppl 1, 2010, pp. S115–19. Pubmed, doi:10.1002/cyto.b.20555.
Caporaso NE, Marti GE, Landgren O, Azzato E, Weinberg JB, Goldin L, Shanafelt T. Monoclonal B cell lymphocytosis: clinical and population perspectives. Cytometry B Clin Cytom. 2010;78 Suppl 1(Suppl 1):S115–S119.
Journal cover image

Published In

Cytometry B Clin Cytom

DOI

EISSN

1552-4957

Publication Date

2010

Volume

78 Suppl 1

Issue

Suppl 1

Start / End Page

S115 / S119

Location

United States

Related Subject Headings

  • Tissue Donors
  • Risk Factors
  • Lymphocytosis
  • Lymphocyte Count
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Immunology
  • Humans
  • Disease Progression
  • Clone Cells
  • Bone Marrow Transplantation