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Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease.

Publication ,  Journal Article
Welsh, KA; Butters, N; Hughes, JP; Mohs, RC; Heyman, A
Published in: Arch Neurol
May 1992

Our earlier studies using the Consortium to Establish a Registry of Alzheimer's Disease neuropsychological battery showed that delayed recall was a highly sensitive indicator of early Alzheimer's disease. None of the learning and memory measures in the battery were found to be useful in staging the severity of this form of dementia. This study explores the nonmemory functions (fluency, naming, and praxis) of the Consortium to Establish a Registry of Alzheimer's Disease battery and asks whether performance on any of these measures adds to the detection of early Alzheimer's disease or is sensitive to the later progression of the illness. We stratified patients with this disease according to severity (mild, moderate, severe), and compared them with age-, education-, and gender-matched control subjects (group N = 49 each). Multivariate procedures and cutting scores were used to determine the efficacy of the various measures in distinguishing between the cases and control subjects. Impairment of delayed recall was again found to be the best discriminator for detecting mild cases of Alzheimer's disease. Confrontation naming was the only nonmemory factor that assisted in this discrimination. For staging the illness, a combination of measures including fluency, praxis, and recognition memory best differentiated cases with mild dementia from those with either moderate or severe stages of disease. Measures of delayed recall quickly "bottomed out" in the patients with Alzheimer's disease and proved of little value in staging the disorder.(ABSTRACT TRUNCATED AT 250 WORDS)

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Published In

Arch Neurol

DOI

ISSN

0003-9942

Publication Date

May 1992

Volume

49

Issue

5

Start / End Page

448 / 452

Location

United States

Related Subject Headings

  • Registries
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Memory
  • Male
  • Language
  • Humans
  • Female
  • Cognition
  • Alzheimer Disease
 

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Welsh, K. A., Butters, N., Hughes, J. P., Mohs, R. C., & Heyman, A. (1992). Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease. Arch Neurol, 49(5), 448–452. https://doi.org/10.1001/archneur.1992.00530290030008
Welsh, K. A., N. Butters, J. P. Hughes, R. C. Mohs, and A. Heyman. “Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease.Arch Neurol 49, no. 5 (May 1992): 448–52. https://doi.org/10.1001/archneur.1992.00530290030008.
Welsh, K. A., et al. “Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease.Arch Neurol, vol. 49, no. 5, May 1992, pp. 448–52. Pubmed, doi:10.1001/archneur.1992.00530290030008.

Published In

Arch Neurol

DOI

ISSN

0003-9942

Publication Date

May 1992

Volume

49

Issue

5

Start / End Page

448 / 452

Location

United States

Related Subject Headings

  • Registries
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Memory
  • Male
  • Language
  • Humans
  • Female
  • Cognition
  • Alzheimer Disease