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Advances in combined radiation therapy for the management of rectal cancer.

Publication ,  Journal Article
Kachnic, LA; Shih, HA; Willett, CG
Published in: Expert Rev Anticancer Ther
August 2003

Significant advances have been made in the use of adjuvant radiation for patients with localized rectal cancer. Recent progress in adjuvant postoperative radiation regimens relates to the integration of systemic therapy into radiation, as well as redefining the techniques and sequences for both modalities. The adjuvant radiation management approach in both North America and Europe has been shifting towards preoperative adjuvant therapy to promote sphincter-preserving surgery and to decrease acute and late toxicity. Although 5-fluorouracil-based chemotherapy in combination with radiation remains the standard adjuvant therapy for rectal cancer, the integration of novel chemotherapeutic agents and biologic modulators remains an active area of investigation.

Duke Scholars

Published In

Expert Rev Anticancer Ther

DOI

ISSN

1473-7140

Publication Date

August 2003

Volume

3

Issue

4

Start / End Page

471 / 483

Location

England

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Humans
  • Combined Modality Therapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Chicago
ICMJE
MLA
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Kachnic, L. A., Shih, H. A., & Willett, C. G. (2003). Advances in combined radiation therapy for the management of rectal cancer. Expert Rev Anticancer Ther, 3(4), 471–483. https://doi.org/10.1586/14737140.3.4.471
Kachnic, Lisa A., Helen A. Shih, and Christopher G. Willett. “Advances in combined radiation therapy for the management of rectal cancer.Expert Rev Anticancer Ther 3, no. 4 (August 2003): 471–83. https://doi.org/10.1586/14737140.3.4.471.
Kachnic LA, Shih HA, Willett CG. Advances in combined radiation therapy for the management of rectal cancer. Expert Rev Anticancer Ther. 2003 Aug;3(4):471–83.
Kachnic, Lisa A., et al. “Advances in combined radiation therapy for the management of rectal cancer.Expert Rev Anticancer Ther, vol. 3, no. 4, Aug. 2003, pp. 471–83. Pubmed, doi:10.1586/14737140.3.4.471.
Kachnic LA, Shih HA, Willett CG. Advances in combined radiation therapy for the management of rectal cancer. Expert Rev Anticancer Ther. 2003 Aug;3(4):471–483.

Published In

Expert Rev Anticancer Ther

DOI

ISSN

1473-7140

Publication Date

August 2003

Volume

3

Issue

4

Start / End Page

471 / 483

Location

England

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Humans
  • Combined Modality Therapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis