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Adjuvant postoperative radiation therapy for rectal adenocarcinoma.

Publication ,  Journal Article
Willett, CG; Tepper, JE; Kaufman, DS; Shellito, PC; Eliseo, R; Convery, K; Wood, WC
Published in: Am J Clin Oncol
October 1992

From October 1975 to August 1988, 261 patients at high risk for local recurrence after curative resection of rectal carcinoma underwent high-dose postoperative irradiation. Patients received 45 Gy by a 4-field box usually followed by a boost to 50.4 Gy or higher when small bowel could be excluded from the reduced field. Since January 1986, patients also received 5-fluorouracil (5-FU) for 3 consecutive days during the first and last week of radiotherapy. Five-year actuarial local control and disease-free survival decreased with increasing stage of disease; patients with Stage B2 and B3 disease had local control rates of 83% and 87% and disease-free survivals of 55% and 74%, respectively. In patients with Stage C1 through C3 tumors, local control rates ranged from 76% to 23%, and disease-free survivals ranged from 62% to 10%, respectively. For patients with Stage C disease, disease-free survival decreased progressively with increasing lymph node involvement, but local control was independent of the extent of lymph node involvement. For each stage of disease, local control and disease-free survival did not correlate with the dose of pelvic irradiation. Preliminary data from this study suggest a trend toward improved local control for patients with Stage B2, C1, and C2 tumors who receive 5-FU for 3 consecutive days during the first and last weeks of irradiation compared with patients who do not receive 5-FU. Current prospective randomized studies are addressing questions regarding the optimum administration of chemotherapy with pelvic irradiation for patients following resection of rectal carcinoma.

Duke Scholars

Published In

Am J Clin Oncol

DOI

ISSN

0277-3732

Publication Date

October 1992

Volume

15

Issue

5

Start / End Page

371 / 375

Location

United States

Related Subject Headings

  • Survival Analysis
  • Rectal Neoplasms
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Fluorouracil
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Willett, C. G., Tepper, J. E., Kaufman, D. S., Shellito, P. C., Eliseo, R., Convery, K., & Wood, W. C. (1992). Adjuvant postoperative radiation therapy for rectal adenocarcinoma. Am J Clin Oncol, 15(5), 371–375. https://doi.org/10.1097/00000421-199210000-00001
Willett, C. G., J. E. Tepper, D. S. Kaufman, P. C. Shellito, R. Eliseo, K. Convery, and W. C. Wood. “Adjuvant postoperative radiation therapy for rectal adenocarcinoma.Am J Clin Oncol 15, no. 5 (October 1992): 371–75. https://doi.org/10.1097/00000421-199210000-00001.
Willett CG, Tepper JE, Kaufman DS, Shellito PC, Eliseo R, Convery K, et al. Adjuvant postoperative radiation therapy for rectal adenocarcinoma. Am J Clin Oncol. 1992 Oct;15(5):371–5.
Willett, C. G., et al. “Adjuvant postoperative radiation therapy for rectal adenocarcinoma.Am J Clin Oncol, vol. 15, no. 5, Oct. 1992, pp. 371–75. Pubmed, doi:10.1097/00000421-199210000-00001.
Willett CG, Tepper JE, Kaufman DS, Shellito PC, Eliseo R, Convery K, Wood WC. Adjuvant postoperative radiation therapy for rectal adenocarcinoma. Am J Clin Oncol. 1992 Oct;15(5):371–375.

Published In

Am J Clin Oncol

DOI

ISSN

0277-3732

Publication Date

October 1992

Volume

15

Issue

5

Start / End Page

371 / 375

Location

United States

Related Subject Headings

  • Survival Analysis
  • Rectal Neoplasms
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Fluorouracil