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A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression

Publication ,  Journal Article
Guy, W; Wilson, WH; Ban, TA
Published in: Drug Development Research
1984

Fluvoxamine, a new serotonin-reuptake inhibitor, and imipramine were compared under double-blind conditions in 36 unipolar and bipolar depressed inpatients. Both drugs produced significant reductions in depressive symptomatology over a 4-6-wk course of treatment, with the greater part of the improvement occurring in the first 2 wk. No statistically significant differences were obtained between the two drugs. Adverse reactions, particularly anticholinergic ones, were much less frequenty observed in the fluvoxamine group. No clinically significant laboratory abnormalities were reported for either treatment; but minor ECG irregularities were seen under both treatments. The findings generally correspond to results obtained in previous comparative clinical trials.

Duke Scholars

Published In

Drug Development Research

Publication Date

1984

Volume

4

Issue

2

Start / End Page

143 / 153

Related Subject Headings

  • Pharmacology & Pharmacy
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Guy, W., Wilson, W. H., & Ban, T. A. (1984). A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression. Drug Development Research, 4(2), 143–153.
Guy, W., W. H. Wilson, and T. A. Ban. “A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression.” Drug Development Research 4, no. 2 (1984): 143–53.
Guy W, Wilson WH, Ban TA. A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression. Drug Development Research. 1984;4(2):143–53.
Guy, W., et al. “A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression.” Drug Development Research, vol. 4, no. 2, 1984, pp. 143–53.
Guy W, Wilson WH, Ban TA. A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression. Drug Development Research. 1984;4(2):143–153.

Published In

Drug Development Research

Publication Date

1984

Volume

4

Issue

2

Start / End Page

143 / 153

Related Subject Headings

  • Pharmacology & Pharmacy
  • 1115 Pharmacology and Pharmaceutical Sciences