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Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice.

Publication ,  Journal Article
Anisimov, VN; Alimova, IN; Baturin, DA; Popovich, IG; Zabezhinski, MA; Rosenfeld, SV; Manton, KG; Semenchenko, AV; Yashin, AI
Published in: Experimental gerontology
April 2003

From the age of 3 months until their natural death, female Swiss-derived SHR mice were given melatonin with their drinking water (2 or 20mg/l) for 5 consecutive days every month. Intact mice served as controls. There were 54 mice in each group. The results of this study show that the treatment of melatonin did not significantly influence food consumption, but its administration at lower doses did decrease the body weight of mice; it slowed down the age-related switching-off of estrous function; it did not influence the frequency of chromosome aberrations in bone marrow cells; it did not influence mean life span; and it increased life span of the last 10% of the survivors in comparison to controls. We also found that treatment with low dose melatonin (2mg/l) significantly decreased spontaneous tumor incidence (by 1,9-fold), mainly mammary carcinomas, in mice whereas higher doses (20mg/l) failed to influence tumor incidence as compared to controls. For this reason, we conclude that the effect of melatonin as a geroprotector is dose-dependent.

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Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

April 2003

Volume

38

Issue

4

Start / End Page

449 / 461

Related Subject Headings

  • Random Allocation
  • Neoplasms
  • Mice, Inbred Strains
  • Mice
  • Melatonin
  • Longevity
  • Incidence
  • Gerontology
  • Female
  • Estrus
 

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Anisimov, V. N., Alimova, I. N., Baturin, D. A., Popovich, I. G., Zabezhinski, M. A., Rosenfeld, S. V., … Yashin, A. I. (2003). Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice. Experimental Gerontology, 38(4), 449–461. https://doi.org/10.1016/s0531-5565(02)00240-1
Anisimov, Vladimir N., Irina N. Alimova, Dmitri A. Baturin, Irina G. Popovich, Mark A. Zabezhinski, Svetlana V. Rosenfeld, Kenneth G. Manton, Anna V. Semenchenko, and Anatoli I. Yashin. “Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice.Experimental Gerontology 38, no. 4 (April 2003): 449–61. https://doi.org/10.1016/s0531-5565(02)00240-1.
Anisimov VN, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Rosenfeld SV, et al. Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice. Experimental gerontology. 2003 Apr;38(4):449–61.
Anisimov, Vladimir N., et al. “Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice.Experimental Gerontology, vol. 38, no. 4, Apr. 2003, pp. 449–61. Epmc, doi:10.1016/s0531-5565(02)00240-1.
Anisimov VN, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Rosenfeld SV, Manton KG, Semenchenko AV, Yashin AI. Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice. Experimental gerontology. 2003 Apr;38(4):449–461.
Journal cover image

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

April 2003

Volume

38

Issue

4

Start / End Page

449 / 461

Related Subject Headings

  • Random Allocation
  • Neoplasms
  • Mice, Inbred Strains
  • Mice
  • Melatonin
  • Longevity
  • Incidence
  • Gerontology
  • Female
  • Estrus