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High-resolution imaging of progressive articular cartilage degeneration.

Publication ,  Journal Article
Adams, SB; Herz, PR; Stamper, DL; Roberts, MJ; Bourquin, S; Patel, NA; Schneider, K; Martin, SD; Shortkroff, S; Fujimoto, JG; Brezinski, ME
Published in: J Orthop Res
April 2006

The objective of this study was to develop and verify a new technique for monitoring the progression of osteoarthritis (OA) by combining a rat model with the imaging modality optical coherence tomography (OCT). Time-sequential, in vivo, OCT imaging was performed on the left femoral condyles of 12 Wistar rats following sodium-iodoacetic acid-induced OA progression. The right femoral condyles (untreated) were also imaged and served as controls. Imaging was performed on days 0, 10, 20, 30, and 60 with an OCT system capable of acquiring images at four frames per second and an axial resolution of 5 microm. Progressive changes were analyzed using an OA scoring system. OCT successfully identified progressive cartilage degeneration as well as alteration of the cartilage/bone interface. Significant changes to both of these structures were observed in the sodium-iodoacetic acid-injected condyles. Structural changes detected with OCT were confirmed histologically. OCT in combination with a well-known model used in arthritis research represents a powerful tool for following degenerative joint disease progression in a given animal by detecting changes to the cartilage/bone interface and articular cartilage.

Duke Scholars

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

April 2006

Volume

24

Issue

4

Start / End Page

708 / 715

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Rats, Wistar
  • Rats, Inbred Lew
  • Rats
  • Osteoarthritis
  • Orthopedics
  • Male
  • Iodoacetates
  • Disease Models, Animal
  • Cartilage, Articular
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Adams, S. B., Herz, P. R., Stamper, D. L., Roberts, M. J., Bourquin, S., Patel, N. A., … Brezinski, M. E. (2006). High-resolution imaging of progressive articular cartilage degeneration. J Orthop Res, 24(4), 708–715. https://doi.org/10.1002/jor.20083
Adams, Samuel B., Paul R. Herz, Debra L. Stamper, Mark J. Roberts, Stephane Bourquin, Nirlep A. Patel, Karl Schneider, et al. “High-resolution imaging of progressive articular cartilage degeneration.J Orthop Res 24, no. 4 (April 2006): 708–15. https://doi.org/10.1002/jor.20083.
Adams SB, Herz PR, Stamper DL, Roberts MJ, Bourquin S, Patel NA, et al. High-resolution imaging of progressive articular cartilage degeneration. J Orthop Res. 2006 Apr;24(4):708–15.
Adams, Samuel B., et al. “High-resolution imaging of progressive articular cartilage degeneration.J Orthop Res, vol. 24, no. 4, Apr. 2006, pp. 708–15. Pubmed, doi:10.1002/jor.20083.
Adams SB, Herz PR, Stamper DL, Roberts MJ, Bourquin S, Patel NA, Schneider K, Martin SD, Shortkroff S, Fujimoto JG, Brezinski ME. High-resolution imaging of progressive articular cartilage degeneration. J Orthop Res. 2006 Apr;24(4):708–715.
Journal cover image

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

April 2006

Volume

24

Issue

4

Start / End Page

708 / 715

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Rats, Wistar
  • Rats, Inbred Lew
  • Rats
  • Osteoarthritis
  • Orthopedics
  • Male
  • Iodoacetates
  • Disease Models, Animal
  • Cartilage, Articular