Skip to main content
Journal cover image

Insights on the robust variance estimator under recurrent-events model.

Publication ,  Journal Article
Al-Khalidi, HR; Hong, Y; Fleming, TR; Therneau, TM
Published in: Biometrics
December 2011

Recurrent events are common in medical research for subjects who are followed for the duration of a study. For example, cardiovascular patients with an implantable cardioverter defibrillator (ICD) experience recurrent arrhythmic events that are terminated by shocks or antitachycardia pacing delivered by the device. In a published randomized clinical trial, a recurrent-event model was used to study the effect of a drug therapy in subjects with ICDs, who were experiencing recurrent symptomatic arrhythmic events. Under this model, one expects the robust variance for the estimated treatment effect to diminish when the duration of the trial is extended, due to the additional events observed. However, as shown in this article, that is not always the case. We investigate this phenomenon using large datasets from this arrhythmia trial and from a diabetes study, with some analytical results, as well as through simulations. Some insights are also provided on existing sample size formulae using our results.

Duke Scholars

Published In

Biometrics

DOI

EISSN

1541-0420

Publication Date

December 2011

Volume

67

Issue

4

Start / End Page

1564 / 1572

Location

England

Related Subject Headings

  • Treatment Outcome
  • Statistics & Probability
  • Secondary Prevention
  • Proportional Hazards Models
  • Prevalence
  • Outcome Assessment, Health Care
  • Models, Statistical
  • Diabetes Mellitus
  • Data Interpretation, Statistical
  • Computer Simulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Al-Khalidi, H. R., Hong, Y., Fleming, T. R., & Therneau, T. M. (2011). Insights on the robust variance estimator under recurrent-events model. Biometrics, 67(4), 1564–1572. https://doi.org/10.1111/j.1541-0420.2011.01589.x
Al-Khalidi, Hussein R., Yili Hong, Thomas R. Fleming, and Terry M. Therneau. “Insights on the robust variance estimator under recurrent-events model.Biometrics 67, no. 4 (December 2011): 1564–72. https://doi.org/10.1111/j.1541-0420.2011.01589.x.
Al-Khalidi HR, Hong Y, Fleming TR, Therneau TM. Insights on the robust variance estimator under recurrent-events model. Biometrics. 2011 Dec;67(4):1564–72.
Al-Khalidi, Hussein R., et al. “Insights on the robust variance estimator under recurrent-events model.Biometrics, vol. 67, no. 4, Dec. 2011, pp. 1564–72. Pubmed, doi:10.1111/j.1541-0420.2011.01589.x.
Al-Khalidi HR, Hong Y, Fleming TR, Therneau TM. Insights on the robust variance estimator under recurrent-events model. Biometrics. 2011 Dec;67(4):1564–1572.
Journal cover image

Published In

Biometrics

DOI

EISSN

1541-0420

Publication Date

December 2011

Volume

67

Issue

4

Start / End Page

1564 / 1572

Location

England

Related Subject Headings

  • Treatment Outcome
  • Statistics & Probability
  • Secondary Prevention
  • Proportional Hazards Models
  • Prevalence
  • Outcome Assessment, Health Care
  • Models, Statistical
  • Diabetes Mellitus
  • Data Interpretation, Statistical
  • Computer Simulation