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Recovery from hospital-acquired anemia after acute myocardial infarction and effect on outcomes.

Publication ,  Journal Article
Salisbury, AC; Kosiborod, M; Amin, AP; Reid, KJ; Alexander, KP; Spertus, JA; Masoudi, FA
Published in: Am J Cardiol
October 1, 2011

New-onset, hospital-acquired anemia (HAA) during acute myocardial infarction (AMI) is independently associated with poor outcomes. The patterns of recovery from HAA after AMI and their association with mortality and health status are unknown. In the prospective 24-center Translational Research Investigating Underlying disparities in acute myocardial infarction Patients' Health Status (TRIUMPH) registry, we identified 530 patients with AMI and HAA (defined as normal hemoglobin at admission with the development of anemia by discharge) who had a repeat, protocol-driven hemoglobin measurement at 1 month after discharge. The 1-month measures were used to define persistent (persistent anemia) and transient (anemia resolved) HAA. The patients' health status was assessed at 1, 6, and 12 months after AMI using the Short-Form 12 Physical Component Summary, and the health status of patients with persistent and transient HAA was compared using multivariate repeated measures regression analysis. Mortality was compared using the log-rank test and proportional hazards regression analysis. Overall, 165 patients (31%) developed persistent HAA. The adjusted mean Short-Form 12 Physical Component Summary scores at the follow-up visit were significantly lower in those with persistent HAA than in those with transient HAA (-2.0 points, 95% confidence interval -3.6 to -0.3; p = 0.02). During a median follow-up of 36 months, the crude mortality (13% vs 5%, p = 0.002) and multivariate-adjusted mortality (hazard ratio 2.08, 95% confidence interval 1.02 to 4.21, p = 0.04) was greater in patients with persistent HAA. In conclusion, HAA persists 1 month after discharge in nearly 1 of 3 patients and is associated with worse health status and greater mortality. Additional investigation is needed to understand whether HAA prevention, recognition, and treatment, particularly among those with persistent HAA, will improve outcomes.

Duke Scholars

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 1, 2011

Volume

108

Issue

7

Start / End Page

949 / 954

Location

United States

Related Subject Headings

  • United States
  • Survival Rate
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Patient Discharge
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Salisbury, A. C., Kosiborod, M., Amin, A. P., Reid, K. J., Alexander, K. P., Spertus, J. A., & Masoudi, F. A. (2011). Recovery from hospital-acquired anemia after acute myocardial infarction and effect on outcomes. Am J Cardiol, 108(7), 949–954. https://doi.org/10.1016/j.amjcard.2011.05.026
Salisbury, Adam C., Mikhail Kosiborod, Amit P. Amin, Kimberly J. Reid, Karen P. Alexander, John A. Spertus, and Frederick A. Masoudi. “Recovery from hospital-acquired anemia after acute myocardial infarction and effect on outcomes.Am J Cardiol 108, no. 7 (October 1, 2011): 949–54. https://doi.org/10.1016/j.amjcard.2011.05.026.
Salisbury AC, Kosiborod M, Amin AP, Reid KJ, Alexander KP, Spertus JA, et al. Recovery from hospital-acquired anemia after acute myocardial infarction and effect on outcomes. Am J Cardiol. 2011 Oct 1;108(7):949–54.
Salisbury, Adam C., et al. “Recovery from hospital-acquired anemia after acute myocardial infarction and effect on outcomes.Am J Cardiol, vol. 108, no. 7, Oct. 2011, pp. 949–54. Pubmed, doi:10.1016/j.amjcard.2011.05.026.
Salisbury AC, Kosiborod M, Amin AP, Reid KJ, Alexander KP, Spertus JA, Masoudi FA. Recovery from hospital-acquired anemia after acute myocardial infarction and effect on outcomes. Am J Cardiol. 2011 Oct 1;108(7):949–954.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 1, 2011

Volume

108

Issue

7

Start / End Page

949 / 954

Location

United States

Related Subject Headings

  • United States
  • Survival Rate
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Patient Discharge
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Incidence