The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site
Publication
, Journal Article
Lo, HW; Ali-Osman, F
Published in: Chemico-Biological Interactions
February 28, 2001
The human GSTP1 gene is frequently up-regulated in human malignancies and is associated with resistance to chemotherapy and an aggressive biology. Presently, however, the molecular mechanisms involved in the regulation of this gene are not well understood. We report here the transcriptional activation of the human GSTP1 gene by the second messenger, cAMP, in human tumor cells and provide evidence that this occurs via a CRE and the AP-1 site in the 5′-regulatory region of the GSTP1 gene. The data support cAMP signaling pathways in mechanisms of GSTP1 gene regulation. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Duke Scholars
Published In
Chemico-Biological Interactions
ISSN
0009-2797
Publication Date
February 28, 2001
Volume
133
Issue
1-3
Start / End Page
320 / 321
Related Subject Headings
- Toxicology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lo, H. W., & Ali-Osman, F. (2001). The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site. Chemico-Biological Interactions, 133(1–3), 320–321.
Lo, H. W., and F. Ali-Osman. “The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site.” Chemico-Biological Interactions 133, no. 1–3 (February 28, 2001): 320–21.
Lo HW, Ali-Osman F. The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site. Chemico-Biological Interactions. 2001 Feb 28;133(1–3):320–1.
Lo, H. W., and F. Ali-Osman. “The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site.” Chemico-Biological Interactions, vol. 133, no. 1–3, Feb. 2001, pp. 320–21.
Lo HW, Ali-Osman F. The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site. Chemico-Biological Interactions. 2001 Feb 28;133(1–3):320–321.
Published In
Chemico-Biological Interactions
ISSN
0009-2797
Publication Date
February 28, 2001
Volume
133
Issue
1-3
Start / End Page
320 / 321
Related Subject Headings
- Toxicology
- 0601 Biochemistry and Cell Biology