Scholars@Duke publication: Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.

Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.

Publication , Journal Article

Meissner, G; Rousseau, E; Lai, FA; Liu, QY; Anderson, KA

Published in: Mol Cell Biochem

1988

Rapid mixing-vesicle ion flux and planar lipid bilayer-single channel measurements have shown that a high-conductance, ligand-gated Ca2+ release channel is present in 'heavy', junctional-derived membrane fractions of skeletal and cardiac muscle sarcoplasmic reticulum. Using the release channel-specific probe, ryanodine, a 30S protein complex composed of polypeptides of Mr approximately 400,000 has been isolated from cardiac and skeletal muscle. Reconstitution of the complex into planar lipid bilayers has revealed a Ca2+ conductance with properties characteristic of the native Ca2+ release channel.

Duke Scholars

Author Kristin Ann Anderson Pharmacology & Cancer Biology

Published In

Mol Cell Biochem

DOI

10.1007/BF00242517

ISSN

0300-8177

Publication Date

1988

Volume

Issue

1-2

Start / End Page

59 / 65

Location

Netherlands

Related Subject Headings

Sarcoplasmic Reticulum
Ryanodine
Myocardium
Muscles
Magnesium
In Vitro Techniques
Calmodulin
Calcium Channels
Calcium
Caffeine

Citation

APA

Chicago

ICMJE

MLA

NLM

Meissner, G., Rousseau, E., Lai, F. A., Liu, Q. Y., & Anderson, K. A. (1988). Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum. Mol Cell Biochem, 82(1–2), 59–65. https://doi.org/10.1007/BF00242517

Meissner, G., E. Rousseau, F. A. Lai, Q. Y. Liu, and K. A. Anderson. “Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.” Mol Cell Biochem 82, no. 1–2 (1988): 59–65. https://doi.org/10.1007/BF00242517.

Meissner G, Rousseau E, Lai FA, Liu QY, Anderson KA. Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum. Mol Cell Biochem. 1988;82(1–2):59–65.

Meissner, G., et al. “Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.” Mol Cell Biochem, vol. 82, no. 1–2, 1988, pp. 59–65. Pubmed, doi:10.1007/BF00242517.

Meissner G, Rousseau E, Lai FA, Liu QY, Anderson KA. Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum. Mol Cell Biochem. 1988;82(1–2):59–65.