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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

Publication ,  Journal Article
Donovan, A; Lima, CA; Pinkus, JL; Pinkus, GS; Zon, LI; Robine, S; Andrews, NC
Published in: Cell metabolism
March 2005

Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide, binds to ferroportin and causes it to be internalized and degraded. If ferroportin is the major cellular iron exporter, ineffective hepcidin function could explain manifestations of human hemochromatosis disorders. To investigate this, we inactivated the murine ferroportin (Fpn) gene globally and selectively. Embryonic lethality of Fpn(null/null) animals indicated that ferroportin is essential early in development. Rescue of embryonic lethality through selective inactivation of ferroportin in the embryo proper suggested that ferroportin has an important function in the extraembryonic visceral endoderm. Ferroportin-deficient animals accumulated iron in enterocytes, macrophages, and hepatocytes, consistent with a key role for ferroportin in those cell types. Intestine-specific inactivation of ferroportin confirmed that it is critical for intestinal iron absorption. These observations define the major sites of ferroportin activity and give insight into hemochromatosis.

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Published In

Cell metabolism

DOI

EISSN

1932-7420

ISSN

1550-4131

Publication Date

March 2005

Volume

1

Issue

3

Start / End Page

191 / 200

Related Subject Headings

  • Mice, Knockout
  • Mice
  • Macrophages
  • Iron
  • Intestinal Absorption
  • Homeostasis
  • Hepatocytes
  • Enterocytes
  • Endoderm
  • Endocrinology & Metabolism
 

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Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005). The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metabolism, 1(3), 191–200. https://doi.org/10.1016/j.cmet.2005.01.003
Donovan, Adriana, Christine A. Lima, Jack L. Pinkus, Geraldine S. Pinkus, Leonard I. Zon, Sylvie Robine, and Nancy C. Andrews. “The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.Cell Metabolism 1, no. 3 (March 2005): 191–200. https://doi.org/10.1016/j.cmet.2005.01.003.
Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell metabolism. 2005 Mar;1(3):191–200.
Donovan, Adriana, et al. “The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.Cell Metabolism, vol. 1, no. 3, Mar. 2005, pp. 191–200. Epmc, doi:10.1016/j.cmet.2005.01.003.
Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell metabolism. 2005 Mar;1(3):191–200.
Journal cover image

Published In

Cell metabolism

DOI

EISSN

1932-7420

ISSN

1550-4131

Publication Date

March 2005

Volume

1

Issue

3

Start / End Page

191 / 200

Related Subject Headings

  • Mice, Knockout
  • Mice
  • Macrophages
  • Iron
  • Intestinal Absorption
  • Homeostasis
  • Hepatocytes
  • Enterocytes
  • Endoderm
  • Endocrinology & Metabolism