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Platelet functions beyond hemostasis.

Publication ,  Journal Article
Smyth, SS; McEver, RP; Weyrich, AS; Morrell, CN; Hoffman, MR; Arepally, GM; French, PA; Dauerman, HL; Becker, RC ...
Published in: J Thromb Haemost
November 2009

Although their central role is in the prevention of bleeding, platelets probably contribute to diverse processes that extend beyond hemostasis and thrombosis. For example, platelets can recruit leukocytes and progenitor cells to sites of vascular injury and inflammation; they release proinflammatory and anti-inflammatory and angiogenic factors and microparticles into the circulation; and they spur thrombin generation. Data from animal models suggest that these functions may contribute to atherosclerosis, sepsis, hepatitis, vascular restenosis, acute lung injury, and transplant rejection. This article represents an integrated summary of presentations given at the Fourth Annual Platelet Colloquium in January 2009. The process of and factors mediating platelet-platelet and platelet-leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P-selectin, chemokines and Src family kinases being highlighted. Also discussed are specific disorders characterized by local or systemic platelet activation, including coronary artery restenosis after percutaneous intervention, alloantibody-mediated transplant rejection, wound healing, and heparin-induced thrombocytopenia.

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Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

November 2009

Volume

7

Issue

11

Start / End Page

1759 / 1766

Location

England

Related Subject Headings

  • Inflammation
  • Immunity
  • Humans
  • Disease
  • Cell Communication
  • Cardiovascular System & Hematology
  • Blood Platelets
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

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Smyth, S. S., McEver, R. P., Weyrich, A. S., Morrell, C. N., Hoffman, M. R., Arepally, G. M., … 2009 Platelet Colloquium Participants, . (2009). Platelet functions beyond hemostasis. J Thromb Haemost, 7(11), 1759–1766. https://doi.org/10.1111/j.1538-7836.2009.03586.x
Smyth, S. S., R. P. McEver, A. S. Weyrich, C. N. Morrell, M. R. Hoffman, G. M. Arepally, P. A. French, H. L. Dauerman, R. C. Becker, and R. C. 2009 Platelet Colloquium Participants. “Platelet functions beyond hemostasis.J Thromb Haemost 7, no. 11 (November 2009): 1759–66. https://doi.org/10.1111/j.1538-7836.2009.03586.x.
Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, et al. Platelet functions beyond hemostasis. J Thromb Haemost. 2009 Nov;7(11):1759–66.
Smyth, S. S., et al. “Platelet functions beyond hemostasis.J Thromb Haemost, vol. 7, no. 11, Nov. 2009, pp. 1759–66. Pubmed, doi:10.1111/j.1538-7836.2009.03586.x.
Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC, 2009 Platelet Colloquium Participants. Platelet functions beyond hemostasis. J Thromb Haemost. 2009 Nov;7(11):1759–1766.
Journal cover image

Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

November 2009

Volume

7

Issue

11

Start / End Page

1759 / 1766

Location

England

Related Subject Headings

  • Inflammation
  • Immunity
  • Humans
  • Disease
  • Cell Communication
  • Cardiovascular System & Hematology
  • Blood Platelets
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences