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Clevidipine in the treatment of perioperative hypertension: assessing safety events in the ECLIPSE trials.

Publication ,  Journal Article
Aronson, S
Published in: Expert Rev Cardiovasc Ther
May 2009

Clevidipine is an arterial, selective, dihydropyridine calcium channel blocker with an ultrashort half-life. In this prospective, randomized, open-label, parallel-comparison trial series, the safety and efficacy of intravenous clevidipine with nitroglycerin, sodium nitroprusside and nicardipine in hypertensive patients during cardiac surgery were compared. No differences in the incidences of myocardial infarction, stroke or renal dysfunction were observed between treatment groups. Mortality was similar between the clevidipine-nitrogylcerine- and clevidipine-nicardipine-treated groups, whereas mortality appeared to be greater in the sodium nitroprusside group compared to clevidipine (p = 0.04 in a univariant analysis). Clevidipine was significantly more effective in blood pressure control compared with nitroglycerin (p = 0.0006) or sodium nitroprusside (p = 0.003) and was associated with fewer blood pressure excursions compared with nicardipine as a predetermined blood pressure range was narrowed.

Duke Scholars

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

May 2009

Volume

7

Issue

5

Start / End Page

465 / 472

Location

England

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Pyridines
  • Prospective Studies
  • Postoperative Complications
  • Nitroprusside
  • Nitroglycerin
  • Nicardipine
  • Male
  • Intraoperative Complications
  • Infusions, Intravenous
 

Citation

APA
Chicago
ICMJE
MLA
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Aronson, S. (2009). Clevidipine in the treatment of perioperative hypertension: assessing safety events in the ECLIPSE trials. Expert Rev Cardiovasc Ther, 7(5), 465–472. https://doi.org/10.1586/erc.09.1
Aronson, Solomon. “Clevidipine in the treatment of perioperative hypertension: assessing safety events in the ECLIPSE trials.Expert Rev Cardiovasc Ther 7, no. 5 (May 2009): 465–72. https://doi.org/10.1586/erc.09.1.
Aronson, Solomon. “Clevidipine in the treatment of perioperative hypertension: assessing safety events in the ECLIPSE trials.Expert Rev Cardiovasc Ther, vol. 7, no. 5, May 2009, pp. 465–72. Pubmed, doi:10.1586/erc.09.1.
Journal cover image

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

May 2009

Volume

7

Issue

5

Start / End Page

465 / 472

Location

England

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Pyridines
  • Prospective Studies
  • Postoperative Complications
  • Nitroprusside
  • Nitroglycerin
  • Nicardipine
  • Male
  • Intraoperative Complications
  • Infusions, Intravenous